biostudies-literatureUnknown7Pabon-Porras MARheumatoid arthritis and systemic lupus erythematosus are two highly prevalent autoimmune diseases that generate disability and low quality of life. The innate immune system, a long-forgotten issue in autoimmune diseases, is becoming increasingly important and represents a new focus for the treatment of these entities. This review highlights the role that innate immune system plays in the pathophysiology of rheumatoid arthritis and systemic lupus erythematosus. The role of the innate immune system in rheumatoid arthritis and systemic lupus erythematosus pathophysiology is not only important in early stages but is essential to maintain the immune response and to allow disease progression. In rheumatoid arthritis, genetic and environmental factors are involved in the initial stimulation of tSAGE open medicine2050312119876146https://www.ebi.ac.uk/biostudies/studies/S-EPMC8826259biostudies-literatureRheumatoid arthritis and systemic lupus erythematosus: Pathophysiological mechanisms related to innate immune system.PMC8826259Pabon-Porras MACoral-Alvarado PXFlorez-Suarez JBMendez-Patarroyo PMolina-Rios SQuintana-Lopez GfalseRheumatoid arthritis and systemic lupus erythematosus: Pathophysiological mechanisms related to innate immune system.Rheumatoid arthritis and systemic lupus erythematosus are two highly prevalent autoimmune diseases that generate disability and low quality of life. The innate immune system, a long-forgotten issue in autoimmune diseases, is becoming increasingly important and represents a new focus for the treatment of these entities. This review highlights the role that innate immune system plays in the pathophysiology of rheumatoid arthritis and systemic lupus erythematosus. The role of the innate immune system in rheumatoid arthritis and systemic lupus erythematosus pathophysiology is not only important in early stages but is essential to maintain the immune response and to allow disease progression. In rheumatoid arthritis, genetic and environmental factors are involved in the initial stimulation of t2019-01-01T00:00:00Z20192025-04-18T12:11:09.323Z2025-04-06T21:48:02.378ZS-EPMC88262593515475310.1177/2050312119876146