{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Tang L"],"pubmed_abstract":["Psoriasis is a chronic and inflammatory skin disorder characterized by inflammation and epidermal hyperplasia. Punicalagin (PUN) is a main active ingredient of pomegranate (<i>Punica granatum</i> L.) peel with multiple biological activities, such as antibacterial, antioxidant and anti-tumor effects. However, the potential effect of PUN on psoriasis remains unknown. In this study, we want to investigate the pharmacological effect of PUN on psoriasis by using imiquimod (IMQ)-induced psoriatic mice model <i>in vivo</i> and tumor necrosis factor <i>a</i> (TNF-α) and interleukin-17A (IL-17A)-stimulated HaCaT cells <i>in vitro</i>. Our results showed that PUN can effectively alleviate the severity of psoriasis-like symptoms. Mechanistically, PUN potently suppresses the aberrant upregulation of i"],"journal":["Frontiers in pharmacology"],"pagination":["817526"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8826397"],"repository":["biostudies-literature"],"pubmed_title":["Punicalagin Alleviates Psoriasis by Inhibiting NF-κB-Mediated IL-1β Transcription and Caspase-1-Regulated IL-1β Secretion."],"pmcid":["PMC8826397"],"pubmed_authors":["Liu H","Li H","Zheng X","Yang L","Li C","Zhu Y","Lu C","Sun X","Feng B","Dai Z","Li M","Tang L","Qiu X","Li T","Zhang Z","Ye S","Chen Y","Su Z","Li B","Zheng G","Zhang B","Zhao J"],"additional_accession":[]},"is_claimable":false,"name":"Punicalagin Alleviates Psoriasis by Inhibiting NF-κB-Mediated IL-1β Transcription and Caspase-1-Regulated IL-1β Secretion.","description":"Psoriasis is a chronic and inflammatory skin disorder characterized by inflammation and epidermal hyperplasia. Punicalagin (PUN) is a main active ingredient of pomegranate (<i>Punica granatum</i> L.) peel with multiple biological activities, such as antibacterial, antioxidant and anti-tumor effects. However, the potential effect of PUN on psoriasis remains unknown. In this study, we want to investigate the pharmacological effect of PUN on psoriasis by using imiquimod (IMQ)-induced psoriatic mice model <i>in vivo</i> and tumor necrosis factor <i>a</i> (TNF-α) and interleukin-17A (IL-17A)-stimulated HaCaT cells <i>in vitro</i>. Our results showed that PUN can effectively alleviate the severity of psoriasis-like symptoms. Mechanistically, PUN potently suppresses the aberrant upregulation of i","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T14:59:22.75Z","creation":"2025-04-04T14:59:22.75Z"},"accession":"S-EPMC8826397","cross_references":{"pubmed":["35153790"],"doi":["10.3389/fphar.2022.817526"]}}