biostudies-literatureUnknown13Tang LPsoriasis is a chronic and inflammatory skin disorder characterized by inflammation and epidermal hyperplasia. Punicalagin (PUN) is a main active ingredient of pomegranate (<i>Punica granatum</i> L.) peel with multiple biological activities, such as antibacterial, antioxidant and anti-tumor effects. However, the potential effect of PUN on psoriasis remains unknown. In this study, we want to investigate the pharmacological effect of PUN on psoriasis by using imiquimod (IMQ)-induced psoriatic mice model <i>in vivo</i> and tumor necrosis factor <i>a</i> (TNF-α) and interleukin-17A (IL-17A)-stimulated HaCaT cells <i>in vitro</i>. Our results showed that PUN can effectively alleviate the severity of psoriasis-like symptoms. Mechanistically, PUN potently suppresses the aberrant upregulation of iFrontiers in pharmacology817526https://www.ebi.ac.uk/biostudies/studies/S-EPMC8826397biostudies-literaturePunicalagin Alleviates Psoriasis by Inhibiting NF-κB-Mediated IL-1β Transcription and Caspase-1-Regulated IL-1β Secretion.PMC8826397Liu HLi HZheng XYang LLi CZhu YLu CSun XFeng BDai ZLi MTang LQiu XLi TZhang ZYe SChen YSu ZLi BZheng GZhang BZhao JfalsePunicalagin Alleviates Psoriasis by Inhibiting NF-κB-Mediated IL-1β Transcription and Caspase-1-Regulated IL-1β Secretion.Psoriasis is a chronic and inflammatory skin disorder characterized by inflammation and epidermal hyperplasia. Punicalagin (PUN) is a main active ingredient of pomegranate (<i>Punica granatum</i> L.) peel with multiple biological activities, such as antibacterial, antioxidant and anti-tumor effects. However, the potential effect of PUN on psoriasis remains unknown. In this study, we want to investigate the pharmacological effect of PUN on psoriasis by using imiquimod (IMQ)-induced psoriatic mice model <i>in vivo</i> and tumor necrosis factor <i>a</i> (TNF-α) and interleukin-17A (IL-17A)-stimulated HaCaT cells <i>in vitro</i>. Our results showed that PUN can effectively alleviate the severity of psoriasis-like symptoms. Mechanistically, PUN potently suppresses the aberrant upregulation of i2022-01-01T00:00:00Z20222025-04-04T14:59:22.75Z2025-04-04T14:59:22.75ZS-EPMC88263973515379010.3389/fphar.2022.817526