biostudies-literatureChiriboga MGeorge Mason University Department of BioengineeringNIBIB NIH HHSU.S. Naval Research LaboratoryNational Institute of Biomedical Imaging and BioengineeringU.S. Naval Research Laboratory Nanosciences InstituteOffice of Naval Research110-122https://www.ebi.ac.uk/biostudies/studies/S-EPMC8826488biostudies-literatureUnknown126(1)Progress has been made using B-form DNA duplex strands to template chromophores in ordered molecular aggregates known as J-aggregates. These aggregates can exhibit strong electronic coupling, extended coherent lifetimes, and long-range exciton delocalization under appropriate conditions. Certain cyanine dyes such as pseudoisocyanine (PIC) dye have shown a proclivity to form aggregates in specific DNA sequences. In particular, DX-tiles containing nonalternating poly(dA)-poly(dT) dinucleotide tracks (AT-tracks), which template noncovalent PIC dye aggregates, have been demonstrated to exhibit interesting emergent photonic properties. These DNA-based aggregates are referred to as J-bits for their similarity to J-aggregates. Here, we assemble multifluorophore DX-tile scaffolds which template J-The journal of physical chemistry. BUnderstanding Self-Assembled Pseudoisocyanine Dye Aggregates in DNA Nanostructures and Their Exciton Relay Transfer Capabilities.PMC8826488K99EB030013K99 EB030013Mathur DChiriboga MDiaz SAHastman DAVeneziano RMedintz ILMelinger JSfalseUnderstanding Self-Assembled Pseudoisocyanine Dye Aggregates in DNA Nanostructures and Their Exciton Relay Transfer Capabilities.Progress has been made using B-form DNA duplex strands to template chromophores in ordered molecular aggregates known as J-aggregates. These aggregates can exhibit strong electronic coupling, extended coherent lifetimes, and long-range exciton delocalization under appropriate conditions. Certain cyanine dyes such as pseudoisocyanine (PIC) dye have shown a proclivity to form aggregates in specific DNA sequences. In particular, DX-tiles containing nonalternating poly(dA)-poly(dT) dinucleotide tracks (AT-tracks), which template noncovalent PIC dye aggregates, have been demonstrated to exhibit interesting emergent photonic properties. These DNA-based aggregates are referred to as J-bits for their similarity to J-aggregates. Here, we assemble multifluorophore DX-tile scaffolds which template J-2022-01-01T00:00:00Z2022 Jan2025-04-05T13:09:38.943Z2025-04-05T13:09:38.943ZS-EPMC88264883496278710.1021/acs.jpcb.1c09048