{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(1)"],"submitter":["Vu Thi Ngoc B"],"funding":["RadboudUMC Revolving Research Fund","Wellcome Trust"],"pubmed_abstract":["Colistin is widely used in agriculture and aquaculture as prophylaxis, particularly in Asia. Recently, <i>mcr-1</i> and other mobilizable genes conferring colistin resistance have spread globally in community and hospital populations. Characterizing <i>mcr-1</i> mobile genetic elements and host genetic background is important to understand the transmission of this resistance mechanism. We conducted whole-genome sequencing of 94 <i>mcr-1</i>-positive Escherichia coli isolates (Mcr1-Ec isolates) from human and animal feces, food, and water in a community cohort (N = 87) and from clinical specimens from a referral hospital (N = 7) in northern Vietnam. <i>mcr-1</i> was plasmid-borne in 71 and chromosomally carried in 25 (2 isolates contain one copy on chromosome and one copy on a plasmid) of 9"],"journal":["Microbiology spectrum"],"pagination":["e0135621"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8826730"],"repository":["biostudies-literature"],"pubmed_title":["Characterization of Genetic Elements Carrying <i>mcr-1</i> Gene in Escherichia coli from the Community and Hospital Settings in Vietnam."],"pmcid":["PMC8826730"],"pubmed_authors":["Nguyen Thi Tuyet M","Le Van D","Tran Huy H","Penders J","Vu Thi Ngoc B","Chu Thi L","Nguyen Thi Hong T","Le Viet T","Nguyen Thi Ngoc D","van Doorn HR","Wertheim H"],"additional_accession":[]},"is_claimable":false,"name":"Characterization of Genetic Elements Carrying <i>mcr-1</i> Gene in Escherichia coli from the Community and Hospital Settings in Vietnam.","description":"Colistin is widely used in agriculture and aquaculture as prophylaxis, particularly in Asia. Recently, <i>mcr-1</i> and other mobilizable genes conferring colistin resistance have spread globally in community and hospital populations. Characterizing <i>mcr-1</i> mobile genetic elements and host genetic background is important to understand the transmission of this resistance mechanism. We conducted whole-genome sequencing of 94 <i>mcr-1</i>-positive Escherichia coli isolates (Mcr1-Ec isolates) from human and animal feces, food, and water in a community cohort (N = 87) and from clinical specimens from a referral hospital (N = 7) in northern Vietnam. <i>mcr-1</i> was plasmid-borne in 71 and chromosomally carried in 25 (2 isolates contain one copy on chromosome and one copy on a plasmid) of 9","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2026-06-07T03:22:11.723Z","creation":"2025-04-04T23:02:49.521Z"},"accession":"S-EPMC8826730","cross_references":{"pubmed":["35138158"],"doi":["10.1128/spectrum.01356-21"]}}