biostudies-literatureUnknown10(1)Vu Thi Ngoc BRadboudUMC Revolving Research FundWellcome TrustColistin is widely used in agriculture and aquaculture as prophylaxis, particularly in Asia. Recently, <i>mcr-1</i> and other mobilizable genes conferring colistin resistance have spread globally in community and hospital populations. Characterizing <i>mcr-1</i> mobile genetic elements and host genetic background is important to understand the transmission of this resistance mechanism. We conducted whole-genome sequencing of 94 <i>mcr-1</i>-positive Escherichia coli isolates (Mcr1-Ec isolates) from human and animal feces, food, and water in a community cohort (N = 87) and from clinical specimens from a referral hospital (N = 7) in northern Vietnam. <i>mcr-1</i> was plasmid-borne in 71 and chromosomally carried in 25 (2 isolates contain one copy on chromosome and one copy on a plasmid) of 9Microbiology spectrume0135621https://www.ebi.ac.uk/biostudies/studies/S-EPMC8826730biostudies-literatureCharacterization of Genetic Elements Carrying <i>mcr-1</i> Gene in Escherichia coli from the Community and Hospital Settings in Vietnam.PMC8826730Nguyen Thi Tuyet MLe Van DTran Huy HPenders JVu Thi Ngoc BChu Thi LNguyen Thi Hong TLe Viet TNguyen Thi Ngoc Dvan Doorn HRWertheim HfalseCharacterization of Genetic Elements Carrying <i>mcr-1</i> Gene in Escherichia coli from the Community and Hospital Settings in Vietnam.Colistin is widely used in agriculture and aquaculture as prophylaxis, particularly in Asia. Recently, <i>mcr-1</i> and other mobilizable genes conferring colistin resistance have spread globally in community and hospital populations. Characterizing <i>mcr-1</i> mobile genetic elements and host genetic background is important to understand the transmission of this resistance mechanism. We conducted whole-genome sequencing of 94 <i>mcr-1</i>-positive Escherichia coli isolates (Mcr1-Ec isolates) from human and animal feces, food, and water in a community cohort (N = 87) and from clinical specimens from a referral hospital (N = 7) in northern Vietnam. <i>mcr-1</i> was plasmid-borne in 71 and chromosomally carried in 25 (2 isolates contain one copy on chromosome and one copy on a plasmid) of 92022-01-01T00:00:00Z2022 Feb2026-06-07T03:22:11.723Z2025-04-04T23:02:49.521ZS-EPMC88267303513815810.1128/spectrum.01356-21