biostudies-literatureSilveira-Rosa TICVS Scientific Microscopy PlatformFundação para a Ciência e a TecnologiaFundação Bial"la Caixa" FoundationEuropean Research Council“la Caixa” FoundationNature Research Award for Driving Global Impacte13165https://www.ebi.ac.uk/biostudies/studies/S-EPMC8828259biostudies-literatureUnknown55(2)<h4>Objectives</h4>The action of stress hormones, mainly glucocorticoids, starts and coordinates the systemic response to stressful events. The HPA axis activity is predicated on information processing and modulation by upstream centres, such as the hippocampus where adult-born neurons (hABN) have been reported to be an important component in the processing and integration of new information. Still, it remains unclear whether and how hABN regulates HPA axis activity and CORT production, particularly when considering sex differences.<h4>Materials and methods</h4>Using both sexes of a transgenic rat model of cytogenesis ablation (GFAP-Tk rat model), we examined the endocrinological and behavioural effects of disrupting the generation of new astrocytes and neurons within the hippocampal dentaCell proliferationSuppression of adult cytogenesis in the rat brain leads to sex-differentiated disruption of the HPA axis activity.PMC8828259UIDP/50026/2020PPBI-POCI-01-0145-FEDER-022122UIDB/50026/20202019 Brain Sciences1010031872020.02855.CEECINDLCF/PR/HR20/52400020427/14Machado-Santos ARSousa NSilva JMBessa JMCorreia JSRodrigues AJMateus-Pinheiro AAlves NDMartins-Macedo JLoureiro-Campos ESilva MAraujo BSilveira-Rosa TSotiropoulos IPatricio PPinto LfalseSuppression of adult cytogenesis in the rat brain leads to sex-differentiated disruption of the HPA axis activity.<h4>Objectives</h4>The action of stress hormones, mainly glucocorticoids, starts and coordinates the systemic response to stressful events. The HPA axis activity is predicated on information processing and modulation by upstream centres, such as the hippocampus where adult-born neurons (hABN) have been reported to be an important component in the processing and integration of new information. Still, it remains unclear whether and how hABN regulates HPA axis activity and CORT production, particularly when considering sex differences.<h4>Materials and methods</h4>Using both sexes of a transgenic rat model of cytogenesis ablation (GFAP-Tk rat model), we examined the endocrinological and behavioural effects of disrupting the generation of new astrocytes and neurons within the hippocampal denta2022-01-01T00:00:00Z2022 Feb2025-04-04T12:43:35.191Z2025-04-04T12:43:35.191ZS-EPMC88282593497078710.1111/cpr.13165