{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Torres E"],"funding":["NICHD NIH HHS","MEC | Instituto de Salud Carlos III","Ministerio de Economía y Competitividad","EC | Horizon 2020"],"pagination":["E496-E511"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8828271"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["320(3)"],"pubmed_abstract":["Tachykinin (TAC) signaling is an important element in the central control of reproduction. TAC family is mainly composed of substance P (SP), neurokinin A (NKA), and NKB, which bind preferentially to NK1, NK2, and NK3 receptors, respectively. While most studies have focused on the reproductive functions of NKB/NK3R, and to a lesser extent SP/NK1R, the relevance of NK2R, encoded by <i>Tacr2</i>, remains poorly characterized. Here, we address the physiological roles of NK2R in regulating the reproductive axis by characterizing a novel mouse line with congenital ablation of <i>Tacr2</i>. Activation of NK2R evoked acute luteinizing hormone (LH) responses in control mice, similar to those of agonists of NK1R and NK3R. Despite the absence of NK2R, <i>Tacr2</i><sup>-/-</sup> mice displayed only p"],"journal":["American journal of physiology. Endocrinology and metabolism"],"pubmed_title":["Congenital ablation of <i>Tacr2</i> reveals overlapping and redundant roles of NK2R signaling in the control of reproductive axis."],"pmcid":["PMC8828271"],"funding_grant_id":["R01 HD099084","REP-655232","BFU2017-83934-P","R01 HD090151","PIE-00005"],"pubmed_authors":["Pineda R","Navarro VM","Gaytan F","Candenas ML","Heras V","Leon S","Franssen D","Tena-Sempere M","Torres E","Velasco I","Romero-Ruiz A"],"additional_accession":[]},"is_claimable":false,"name":"Congenital ablation of <i>Tacr2</i> reveals overlapping and redundant roles of NK2R signaling in the control of reproductive axis.","description":"Tachykinin (TAC) signaling is an important element in the central control of reproduction. TAC family is mainly composed of substance P (SP), neurokinin A (NKA), and NKB, which bind preferentially to NK1, NK2, and NK3 receptors, respectively. While most studies have focused on the reproductive functions of NKB/NK3R, and to a lesser extent SP/NK1R, the relevance of NK2R, encoded by <i>Tacr2</i>, remains poorly characterized. Here, we address the physiological roles of NK2R in regulating the reproductive axis by characterizing a novel mouse line with congenital ablation of <i>Tacr2</i>. Activation of NK2R evoked acute luteinizing hormone (LH) responses in control mice, similar to those of agonists of NK1R and NK3R. Despite the absence of NK2R, <i>Tacr2</i><sup>-/-</sup> mice displayed only p","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-18T12:11:01.502Z","creation":"2025-04-06T21:49:40.75Z"},"accession":"S-EPMC8828271","cross_references":{"pubmed":["33427049"],"doi":["10.1152/ajpendo.00346.2020"]}}