biostudies-literatureTorres ENICHD NIH HHSMEC | Instituto de Salud Carlos IIIMinisterio de Economía y CompetitividadEC | Horizon 2020E496-E511https://www.ebi.ac.uk/biostudies/studies/S-EPMC8828271biostudies-literatureUnknown320(3)Tachykinin (TAC) signaling is an important element in the central control of reproduction. TAC family is mainly composed of substance P (SP), neurokinin A (NKA), and NKB, which bind preferentially to NK1, NK2, and NK3 receptors, respectively. While most studies have focused on the reproductive functions of NKB/NK3R, and to a lesser extent SP/NK1R, the relevance of NK2R, encoded by <i>Tacr2</i>, remains poorly characterized. Here, we address the physiological roles of NK2R in regulating the reproductive axis by characterizing a novel mouse line with congenital ablation of <i>Tacr2</i>. Activation of NK2R evoked acute luteinizing hormone (LH) responses in control mice, similar to those of agonists of NK1R and NK3R. Despite the absence of NK2R, <i>Tacr2</i>^-/- mice displayed only pAmerican journal of physiology. Endocrinology and metabolismCongenital ablation of <i>Tacr2</i> reveals overlapping and redundant roles of NK2R signaling in the control of reproductive axis.PMC8828271R01 HD099084REP-655232BFU2017-83934-PR01 HD090151PIE-00005Pineda RNavarro VMGaytan FCandenas MLHeras VLeon SFranssen DTena-Sempere MTorres EVelasco IRomero-Ruiz AfalseCongenital ablation of <i>Tacr2</i> reveals overlapping and redundant roles of NK2R signaling in the control of reproductive axis.Tachykinin (TAC) signaling is an important element in the central control of reproduction. TAC family is mainly composed of substance P (SP), neurokinin A (NKA), and NKB, which bind preferentially to NK1, NK2, and NK3 receptors, respectively. While most studies have focused on the reproductive functions of NKB/NK3R, and to a lesser extent SP/NK1R, the relevance of NK2R, encoded by <i>Tacr2</i>, remains poorly characterized. Here, we address the physiological roles of NK2R in regulating the reproductive axis by characterizing a novel mouse line with congenital ablation of <i>Tacr2</i>. Activation of NK2R evoked acute luteinizing hormone (LH) responses in control mice, similar to those of agonists of NK1R and NK3R. Despite the absence of NK2R, <i>Tacr2</i>^-/- mice displayed only p2021-01-01T00:00:00Z2021 Mar2025-04-18T12:11:01.502Z2025-04-06T21:49:40.75ZS-EPMC88282713342704910.1152/ajpendo.00346.2020