{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Dobano C"],"pubmed_abstract":["COVID-19 affects children to a lesser extent than adults but they can still get infected and transmit SARS-CoV-2 to their contacts. Field deployable non-invasive sensitive diagnostic techniques are needed to evaluate the infectivity dynamics of SARS-CoV-2 in pediatric populations and guide public health interventions, particularly if this population is not fully vaccinated. We evaluated the utility of high-throughput Luminex assays to quantify saliva IgM, IgA and IgG antibodies against five SARS-CoV-2 spike (S) and nucleocapsid (N) antigens in a contacts and infectivity longitudinal study in 122 individuals (52 children and 70 adults). We compared saliva versus serum/plasma samples in infected children and adults diagnosed by weekly RT-PCR over 35 days (n=62), and those who consistently te"],"journal":["Frontiers in immunology"],"pagination":["751705"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8828491"],"repository":["biostudies-literature"],"pubmed_title":["Multiplex Antibody Analysis of IgM, IgA and IgG to SARS-CoV-2 in Saliva and Serum From Infected Children and Their Close Contacts."],"pmcid":["PMC8828491"],"pubmed_authors":["Gratacos E","Fernandez de Sevilla M","Alonso S","Moncunill G","Garcia-Miquel A","Codina A","Rodrigo Melero N","Rubio R","Puyol L","Balanza N","Aguilar R","Santano R","Pons Tomas G","Jordan I","Carolis C","Baro B","Fumado V","Cubells M","Garcia-Garcia JJ","Dobano C","Bassat Q","Izquierdo L","Fortuny C","Claverol J","Jimenez A","Girona-Alarcon M","Arias S","Munoz-Almagro C","Millat-Martinez P","Mele Casas M","Barrios D","Hernandez Garcia M","Bonet-Carne E","Vidal M","Ajanovic S"],"additional_accession":[]},"is_claimable":false,"name":"Multiplex Antibody Analysis of IgM, IgA and IgG to SARS-CoV-2 in Saliva and Serum From Infected Children and Their Close Contacts.","description":"COVID-19 affects children to a lesser extent than adults but they can still get infected and transmit SARS-CoV-2 to their contacts. Field deployable non-invasive sensitive diagnostic techniques are needed to evaluate the infectivity dynamics of SARS-CoV-2 in pediatric populations and guide public health interventions, particularly if this population is not fully vaccinated. We evaluated the utility of high-throughput Luminex assays to quantify saliva IgM, IgA and IgG antibodies against five SARS-CoV-2 spike (S) and nucleocapsid (N) antigens in a contacts and infectivity longitudinal study in 122 individuals (52 children and 70 adults). We compared saliva versus serum/plasma samples in infected children and adults diagnosed by weekly RT-PCR over 35 days (n=62), and those who consistently te","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-26T02:01:42.38Z","creation":"2025-02-19T01:34:24.872Z"},"accession":"S-EPMC8828491","cross_references":{"pubmed":["35154094"],"doi":["10.3389/fimmu.2022.751705"]}}