biostudies-literatureMueller MCalypso/VarianAustralian Government NHMRC Senior Principal Research Fellowship and Investigator GrantNCI NIH HHSNational Cancer Institute of the National Institutes of HealthCancer Institute NSW Translational Program Grant1161-1180https://www.ebi.ac.uk/biostudies/studies/S-EPMC8828678biostudies-literatureUnknown49(2)<h4>Purpose</h4>Lung stereotactic ablative body radiotherapy (SABR) is a radiation therapy success story with level 1 evidence demonstrating its efficacy. To provide real-time respiratory motion management for lung SABR, several commercial and preclinical markerless lung target tracking (MLTT) approaches have been developed. However, these approaches have yet to be benchmarked using a common measurement methodology. This knowledge gap motivated the MArkerless lung target Tracking CHallenge (MATCH). The aim was to localize lung targets accurately and precisely in a retrospective in silico study and a prospective experimental study.<h4>Methods</h4>MATCH was an American Association of Physicists in Medicine sponsored Grand Challenge. Common materials for the in silico and experimental studiesMedical physicsThe markerless lung target tracking AAPM Grand Challenge (MATCH) results.PMC8828678P30 CA008748R01 CA188446R01 CA207483R01-CA207483Keall PHansen RRen LMueller MRoeske JCFerguson DVerbakel WBerbeco RMori SPoulsen PWang LZhang PfalseThe markerless lung target tracking AAPM Grand Challenge (MATCH) results.<h4>Purpose</h4>Lung stereotactic ablative body radiotherapy (SABR) is a radiation therapy success story with level 1 evidence demonstrating its efficacy. To provide real-time respiratory motion management for lung SABR, several commercial and preclinical markerless lung target tracking (MLTT) approaches have been developed. However, these approaches have yet to be benchmarked using a common measurement methodology. This knowledge gap motivated the MArkerless lung target Tracking CHallenge (MATCH). The aim was to localize lung targets accurately and precisely in a retrospective in silico study and a prospective experimental study.<h4>Methods</h4>MATCH was an American Association of Physicists in Medicine sponsored Grand Challenge. Common materials for the in silico and experimental studies2022-01-01T00:00:00Z2022 Feb2025-04-19T15:02:48.489Z2025-04-19T15:02:48.489ZS-EPMC88286783491349510.1002/mp.15418