biostudies-literatureYe ZNIDCR NIH HHSNCATS NIH HHS338-349https://www.ebi.ac.uk/biostudies/studies/S-EPMC8828705biostudies-literatureUnknown140Antimicrobial coatings are one of the most promising strategies to prevent bacterial infections in orthopedic and dental implants. Combining antimicrobial agents with different antimicrobial mechanisms might have synergistic effects and be more potent. Others have shown that nanocomposites of silver nanoparticles (AgNPs) decorated with antimicrobial peptides (AMPs) show increased potency as free agents in solution. However, similar nanocomposites have not been explored to coat biomaterials through cooperative weak electrostatic attraction forces between AMP, AgNPs and substrates in need of protection against infection. In this work, we synthesized self-assembled antimicrobial amphiphiles of an AMP, GL13K. Then, we decorated the AMP nanostructures with AgNPs, which were finally used to coatActa biomaterialiaHybrid nanocoatings of self-assembled organic-inorganic amphiphiles for prevention of implant infections.PMC8828705UL1 TR002494R01 DE026117T90 DE022732Kumar DTang ZMutreja IFischer NGSang TLi KAparicio CEcheverria CYe ZfalseHybrid nanocoatings of self-assembled organic-inorganic amphiphiles for prevention of implant infections.Antimicrobial coatings are one of the most promising strategies to prevent bacterial infections in orthopedic and dental implants. Combining antimicrobial agents with different antimicrobial mechanisms might have synergistic effects and be more potent. Others have shown that nanocomposites of silver nanoparticles (AgNPs) decorated with antimicrobial peptides (AMPs) show increased potency as free agents in solution. However, similar nanocomposites have not been explored to coat biomaterials through cooperative weak electrostatic attraction forces between AMP, AgNPs and substrates in need of protection against infection. In this work, we synthesized self-assembled antimicrobial amphiphiles of an AMP, GL13K. Then, we decorated the AMP nanostructures with AgNPs, which were finally used to coat2022-01-01T00:00:00Z2022 Mar2025-04-04T08:54:13.212Z2025-04-04T08:54:13.212ZS-EPMC88287053489663110.1016/j.actbio.2021.12.008