biostudies-literatureUnknown98(6)Jacob MA<h4>Background and objectives</h4>There is a worldwide increase in the incidence of stroke in young adults, with major regional and ethnic differences. Advancing knowledge of ethnic and regional variation in causes and outcomes will be beneficial in implementation of regional health care services. We studied the global distribution of risk factors, causes, and 3-month mortality of young patients with ischemic stroke, by performing a patient data meta-analysis from different cohorts worldwide.<h4>Methods</h4>We performed a pooled analysis of individual patient data from cohort studies that included consecutive patients with ischemic stroke aged 18-50 years. We studied differences in prevalence of risk factors and causes of ischemic stroke between different ethnic and racial groups, geographNeurologye573-e588https://www.ebi.ac.uk/biostudies/studies/S-EPMC8829964biostudies-literatureGlobal Differences in Risk Factors, Etiology, and Outcome of Ischemic Stroke in Young Adults-A Worldwide Meta-analysis: The GOAL Initiative.PMC8829964Enzinger CPutaala JKumar VBandeo LTan KSFromm AKlijn CJMPezzini AFandler-Hofler SFazekas FWu TYJacob MAChuluun BYesilot NWaje-Andreassen UPikula ADagvajantsan BHora TFPacio GVibo RDebette SBrouns RGattringer TJern CJood KKleinig Tvon Sarnowski BKittner SEkizoglu EArauz ABonardo PChuluunbatar EBarboza MAKorv JAllach YSwartz RHArnold MCai MBolognese MLee THMifsud VTanne DPhillips MCViana-Baptista MTatlisumak TPiechowski-Jozwiak BMaaijwee NAMBae HJMartinez-Majander Nde Leeuw FEKim YSTuladhar AMMarto JThijs VMehndiratta MMPatel VBMontanaro VEkker MSDon ARuiz-Sandoval JCordonnier CAarnio KLee KJfalseGlobal Differences in Risk Factors, Etiology, and Outcome of Ischemic Stroke in Young Adults-A Worldwide Meta-analysis: The GOAL Initiative.<h4>Background and objectives</h4>There is a worldwide increase in the incidence of stroke in young adults, with major regional and ethnic differences. Advancing knowledge of ethnic and regional variation in causes and outcomes will be beneficial in implementation of regional health care services. We studied the global distribution of risk factors, causes, and 3-month mortality of young patients with ischemic stroke, by performing a patient data meta-analysis from different cohorts worldwide.<h4>Methods</h4>We performed a pooled analysis of individual patient data from cohort studies that included consecutive patients with ischemic stroke aged 18-50 years. We studied differences in prevalence of risk factors and causes of ischemic stroke between different ethnic and racial groups, geograph2022-01-01T00:00:00Z2022 Feb2025-04-18T16:14:22.605Z2025-04-07T03:19:32.091ZS-EPMC88299643490697410.1212/WNL.000000000001319510.1212/wnl.0000000000013195