biostudies-literaturePankhurst THealth Data Research UKMedical Research CouncilBritish Lung FoundationWellcome TrustAcademy of Medical Sciencese054027https://www.ebi.ac.uk/biostudies/studies/S-EPMC8830252biostudies-literatureUnknown12(2)<h4>Objective</h4>Use of National Early Warning Score 2 (NEWS2) has been mandated in adults admitted to acute hospitals in England. Urgent clinical review is recommended at NEWS2 ≥5. This policy is recognised as requiring ongoing evaluation. We assessed NEWS2 acquisition, alerting at key thresholds and patient outcomes, to understand how response recommendations would affect clinical resource allocation.<h4>Setting</h4>Adult acute hospital in England.<h4>Design</h4>Retrospective observational cohort study.<h4>Participants</h4>100 362 consecutive admissions between November 2018 and July 2019.<h4>Outcome</h4>Death or admission to intensive care unit within 24 hours of a score.<h4>Methods</h4>NEWS2 were assembled as single scores from consecutive 24-hour time frames, (the first NEWS2 termed BMJ openEvaluation of NEWS2 response thresholds in a retrospective observational study from a UK acute hospital.PMC8830252AMS-SGCL5-SapeyHDR-9001HDR-3006LT12-8MR/L008335/1PIONEER 2019HDR-3003HDR-9002Pankhurst TEvison FGyves HBall SSapey EGallier SGkoutos GfalseEvaluation of NEWS2 response thresholds in a retrospective observational study from a UK acute hospital.<h4>Objective</h4>Use of National Early Warning Score 2 (NEWS2) has been mandated in adults admitted to acute hospitals in England. Urgent clinical review is recommended at NEWS2 ≥5. This policy is recognised as requiring ongoing evaluation. We assessed NEWS2 acquisition, alerting at key thresholds and patient outcomes, to understand how response recommendations would affect clinical resource allocation.<h4>Setting</h4>Adult acute hospital in England.<h4>Design</h4>Retrospective observational cohort study.<h4>Participants</h4>100 362 consecutive admissions between November 2018 and July 2019.<h4>Outcome</h4>Death or admission to intensive care unit within 24 hours of a score.<h4>Methods</h4>NEWS2 were assembled as single scores from consecutive 24-hour time frames, (the first NEWS2 termed 2022-01-01T00:00:00Z2022 Feb2025-04-21T15:40:48.959Z2025-04-21T15:40:48.959ZS-EPMC88302523513577010.1136/bmjopen-2021-054027