biostudies-literatureUnknown23(1)Bjornstad EC<h4>Background</h4>Hospitalized patients with SARS-CoV2 develop acute kidney injury (AKI) frequently, yet gaps remain in understanding why adults seem to have higher rates compared to children. Our objectives were to evaluate the epidemiology of SARS-CoV2-related AKI across the age spectrum and determine if known risk factors such as illness severity contribute to its pattern.<h4>Methods</h4>Secondary analysis of ongoing prospective international cohort registry. AKI was defined by KDIGO-creatinine only criteria. Log-linear, logistic and generalized estimating equations assessed odds ratios (OR), risk differences (RD), and 95% confidence intervals (CIs) for AKI and mortality adjusting for sex, pre-existing comorbidities, race/ethnicity, illness severity, and clustering within centers. SensBMC nephrology63https://www.ebi.ac.uk/biostudies/studies/S-EPMC8831033biostudies-literatureSARS-CoV-2 infection increases risk of acute kidney injury in a bimodal age distribution.PMC8831033Venkata CZybin KDAllison MDahhan TIDoddaga PGuru PHouston SAkinyosoye OHoenig BPoynter BSarkar SZaren HAAldossary KMJunia CCRajagopalan LSchoenrade NDixon AEKabara HMSSidhu HEpps SMKodate ARamirez MBouknight DChristie ABKabir HHousenger CSiddiqui NURArroliga AHatharaliyadda BBadr MMarx WNosaka NBrenzel TLyons PGBoman KNewell JCamazine MNSantos LSoni KAbbasi KSierra JGDang TKenney LShah FADugar SKavani HCusson BGoodmanson NHoultham STarabichi YMashina MDjukic VRDevis YChung JBarry SVincent GHasan LSIbrahim ASWallman DAgarwal MWaikar SSWilk DABriceno Bierwirth ACMaisonneuve AGRuiz RSendi PIrby KSaunders HMenu Priya AHusain ABaram MIardino AHamarshi MRout ABurke KRahman RADaga MKYounis MButt ASJovic VSalcido-Montenegro AMalhotra AAkca OKaramourtopoulos MCFleissner ZSharma JSharma MForehand 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BMcGourty MKelly LEArroliga ACKovacevic PChuan BDiLorenzo MSanghavi DMarkotic DKovacevic TGerendai ZDeonarine CSacha GWachs CPTSLZawaydeh QMohamed AVadgaonkar GBesett KRParameswaran SKhan HKrehbiel BDMrozowsk RPapo GSunderkrishnan RPetre HHammers MJNeupane PGoodman MLichtenberg RHarrell ABMohammed MShor SMLiu YMMoriki KDurant HJain AJames RNeupane APecott-Grimm HChin JFranco PMNazir ULin BVachharajani VSayed IADrennan AGonzalez ANjai AOKorsmo RCaceres JDBiehl MBagley MJones AHodgdon KKallies KDaube ATeruel SYHernandez-Montfort JFareeduddin ALenhardt RAldana IBastidas AWoll CBeebe MGreen CLadva BGhavam AGal TGreen MCarev DSkaanland AMcGonagill PWDy RVSmith SJBrauer JBierwirth ABTawheed AMehta RGnanapandithan KCutter GGupta AFitzsimmons ADharmadhikari AGavrilovic SGupta NFarlow CXia YThorsen JBasety SSahoo DSines BJRedfern REHaliru DGTraynor DMSalinas IWunderlich WFyffe ZFlores MNaqvi SAAEichen SVaneenenaam DHaluf SSAshok KRojas LMKasireddy AAulakh BSHayes AMorris SMenon SSt Hill CASadule-Rios NSalas AOrellana GMRaymond AVerma SLaghi FSkidmore CRAlmazyad MAKhandhar PBBurns STripathi SPatel AKColona MBurns KZhang ZSteinberg ATekin AYahia HCollins KSkiles KGole SClark KJarvis JMMcQuesten KAmole TGStrom LRegunath HSchmitz NJNawathe PALizardo AKVMcGuire JKMongoh MNMateus AYLGonzalez-Gonzalez JGChong GEsber ZWilfong EMYamanaka TVela KMiller TLSydney GIKuehne JCavallazzi RSVawer MPetrolwala MBomar JLiendo ARNewsome ASTyagi AMoorthy SAlarifi MIChegondi MBjornstad ECSuslavich KMathur NUber RDapul HRWilson CCoello JLRWinkler JBogojevic MShigemitsu HMilosavljevic JKaur NReilkoff RAMhid NPloetz JCartin-Ceba RMelamed RRBrown CCapers KTissavirasingham FBarletta MHerrera HCapizzi SSattler CLARabee MStojakov DSMcGahey IMMcKinney GGossett KLSugumar SPapani SShim EDowell CADenson JLRich DKotekal DJoseph SMercado JANadiger MAsfina KNPriest ENebi PMcBride CKantas DDePaola RItagaki YBrown MJoseph MZuniga MPEttlinger JRijhwani PZaidi FRodrigues SCarr KMicham JAsghar MSGerard ACM Tofil NIturricha-Caceres MFWeinert CSouder JMMoulton CMNGarner OJinjvadia CUdoh IYarrarapu SNChoudhry AJDomecq JPStulce CWMiller JTierney DMSipsey LEl Kassas MAl-Fares ARameshkumar NRoss RBird PNag NKutner SBBlatz AMGavidia OYObinwanko UBhalala USBaghel VKseibi EMiner BRohtagi IGuillen GMRRaj VSOlsen HAlicie BJhajhria SEngemann MRajendram PArmaignac DLMahdi GMFowler JCarapic VCarter HO'Meara ACrockarell LBroadstreet GMishima YVerghese GMMohabir PKSwigger BSKorn MTaylor MCCarlos CVGarcia MVilella ALGarcia JSpuzzillo AStienecker RSSafi AMartin BCBlackburn BRampon GParris DStevens RRaval AAFiack CZavala SWetherbie ATea KMaccarone JKyo MTotapally BMulrow MAltaher AChanderraj RDubrocq GGlavinic RCherian ABennett NMedina JHenshaw AChaugule AAronson MBruning RDuggal ARaju UHodge JFranks AHarris LAkhter MCheruku SAhmed SGillet ASCooper TGuo SKemble LDe Carvalho HPolic BAhmed FContreras BBukhari AAMayampurath ABrown BRMatute CFJuane ERKolakani NSteuernagle JHAli SADalal SJones TLBollinger DRJones TWGriffey HMesland JBWaller CStevanovic PDEspinoza DFeussom GGoyes DAmamasi NSoto HAKamuram MO'Horo JCQamar SNaimy GGaladanci HLeightle SNason JShrimpton KSanchez YASupena KOrellana GBobos MMMilazzo EMinear SDanesh VCHanna SHeneghan JAPatel KKSingh RSingh SSen ABoronat VLogan MMarkic JPatel LADismang NJain NKFerrari MKoritala TDiaz OSiddiqi NAKashiouris MGGoraya HGilman JCatalasan GTakahashi YBaedorf Kassis ENNasim SSAlmazwaghi SARocawich KRivers PShaikh MAHenin PPoudel SKKnezevic DConjeevaram AWoolman CJNanavati ASmith MWarren KO'Brien CGVega-Terrazas EJerde ABuelens IPerzynski AAbraham JZabala MJSaad BMMantese AJimada IGupta MKPatel UPatel RGajic OPatel KSerfass MFares LDel Nogal GDubuque KArdren SSSmalls OChiotos KTofil NMGist KMRodriguez-Gutierrez RLewandowski EGuenther AMAbualkhair MMalipeddi DPrabhu MOrga JConzales GHTsolinas RKrantz BNagy RHesse KCarrole ELynch LMMazumder NMathew SIgnjatovic DKBarreras NARapista NBudzon SMUtley SAyers SCAlFirm ATKaram OAdmon ACirino JRawal SLMacarambon JMChaudhary ATincher LHeffernan JLBarnes JBandy JASidebottom ABrinks JHefley GAndrijevic ASharafi AParacha MPedraza IDaugherty SKHejna MPiracha MJaiswal RMKoulouras VFambrough TLa Nou AParthiban MMehkri OSuzuki RChandra NBice TJArdalic TCChakola SIvic IDaCar AGeiger GETonna JETimilsina SSierra-HoffmanSantiago HCLumelsky DNAnderson ELMiller ASRajala SPattan VLewis GCWakefield DMahashabde MBurley NBMoore MMichelson APDeo NNSchulte AAllan LSnow WMoore DDodd KWAdiga RNiven ARice RGezawa ASAmer MRHoyt CBurnett RHZabolotskikh IBEschler ATirupathi RPeterson JLAlSharif HMNewman LHassan-Hanga FSaleem AFCamacho-Ortiz AWen AYCampbell BSPalacios AYalamanchili SKOulds FEHamdan ALee STang AMayar EWheeler CAshley DWTang BVissichelli NLiptak RLee GKharbanda AChristopher JGoertzen LNauert KKlindworth KChaitanya SClevenbergh PVargas IStapleton RDMasood SDavis SQAbdurrahman NOntai SVentrone SGarcia MAShinn JOMosier JMAbujazar MDeo NWeber DMRiggle JAlbahrani HAValerio FGilson BHersh MAMFord JRocacorba ASridhar SBansal VWang ALal ABrunk MKWang CWang DWu GJyothisree EDeans STolley APatil RPatil NRetford LZaric MSGesheff MPark PNaeem GKopitko CKusmierski KSimion ALevin NMDarji HEdiga RGonzales GHGiri AMehesz IGranado RCSabov MAlghunaim RPapke JBosnjak IPendleton VWalkey AJAbusalem LYHouse SDunderdale CMarkos MKibbelaar ZKing AKreps LMAid MAIshaque SLutrick KTejada AGharpure VPGonyaw EfalseSARS-CoV-2 infection increases risk of acute kidney injury in a bimodal age distribution.<h4>Background</h4>Hospitalized patients with SARS-CoV2 develop acute kidney injury (AKI) frequently, yet gaps remain in understanding why adults seem to have higher rates compared to children. Our objectives were to evaluate the epidemiology of SARS-CoV2-related AKI across the age spectrum and determine if known risk factors such as illness severity contribute to its pattern.<h4>Methods</h4>Secondary analysis of ongoing prospective international cohort registry. AKI was defined by KDIGO-creatinine only criteria. Log-linear, logistic and generalized estimating equations assessed odds ratios (OR), risk differences (RD), and 95% confidence intervals (CIs) for AKI and mortality adjusting for sex, pre-existing comorbidities, race/ethnicity, illness severity, and clustering within centers. Sens2022-01-01T00:00:00Z2022 Feb2025-04-18T14:03:26.172Z2024-11-09T10:34:27.116ZS-EPMC88310333514457210.1186/s12882-022-02681-2