{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chivu-Economescu M"],"funding":["EU Horizon 2020","Horizon 2020 Framework Programme"],"pagination":["1293-1305"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8831971"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(4)"],"pubmed_abstract":["SARS-CoV-2 vaccines are highly efficient against severe forms of the disease, hospitalization and death. Nevertheless, insufficient protection against several circulating viral variants might suggest waning immunity and the need for an additional vaccine dose. We conducted a longitudinal study on the kinetics and persistence of immune responses in healthcare workers vaccinated with two doses of BNT162b2 mRNA vaccine with or without prior SARS-CoV-2 infection. No new infections were diagnosed during follow-up. At 6 months, post-vaccination or post-infection, despite a downward trend in the level of anti-S IgG antibodies, the neutralizing activity does not decrease significantly, remaining higher than 75% (85.14% for subjects with natural infection, 88.82% for vaccinated after prior infectio"],"journal":["Journal of cellular and molecular medicine"],"pubmed_title":["Kinetics and persistence of cellular and humoral immune responses to SARS-CoV-2 vaccine in healthcare workers with or without prior COVID-19."],"pmcid":["PMC8831971"],"funding_grant_id":["H2020‐SC1‐PHE‐CORONAVIRUS‐2020‐2‐RTD / no. 101016233","H2020-SC1-PHE-CORONAVIRUS-2020-2-RTD / no. 1010162"],"pubmed_authors":["Pitica I","Bleotu C","Necula LG","Matei L","Nedeianu S","Voicu O","Ataman M","Diaconu CC","Chiriac D","Mambet C","Botezatu A","Dragu D","Iancu IV","Chivu-Economescu M","Nastasie A","Sultana C","Radu EL","Grancea C","Neagu A","Ruta SM"],"additional_accession":[]},"is_claimable":false,"name":"Kinetics and persistence of cellular and humoral immune responses to SARS-CoV-2 vaccine in healthcare workers with or without prior COVID-19.","description":"SARS-CoV-2 vaccines are highly efficient against severe forms of the disease, hospitalization and death. Nevertheless, insufficient protection against several circulating viral variants might suggest waning immunity and the need for an additional vaccine dose. We conducted a longitudinal study on the kinetics and persistence of immune responses in healthcare workers vaccinated with two doses of BNT162b2 mRNA vaccine with or without prior SARS-CoV-2 infection. No new infections were diagnosed during follow-up. At 6 months, post-vaccination or post-infection, despite a downward trend in the level of anti-S IgG antibodies, the neutralizing activity does not decrease significantly, remaining higher than 75% (85.14% for subjects with natural infection, 88.82% for vaccinated after prior infectio","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-04T08:01:41.726Z","creation":"2025-04-04T08:01:41.726Z"},"accession":"S-EPMC8831971","cross_references":{"pubmed":["35043552"],"doi":["10.1111/jcmm.17186"]}}