{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wright JS"],"funding":["NIBIB NIH HHS","National Institute of General Medical Sciences","National Institute of Biomedical Imaging and Bioengineering","NIGMS NIH HHS"],"pagination":["6915-6921"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8832069"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["143(18)"],"pubmed_abstract":["This article describes a sequential Ir/Cu-mediated process for the <i>meta-</i>selective C-H radiofluorination of (hetero)arene substrates. In the first step, Ir-catalyzed C(sp<sup>2</sup>)-H borylation affords (hetero)aryl pinacolboronate (BPin) esters. The intermediate organoboronates are then directly subjected to copper-mediated radiofluorination with [<sup>18</sup>F]tetrabutylammonium fluoride to afford fluorine-18 labeled (hetero)arenes in high radiochemical yield and radiochemical purity. This entire process is performed on a benchtop without Schlenk or glovebox techniques and circumvents the need to isolate (hetero)aryl boronate esters. The reaction was automated on a TracerLab FX<sub>FN</sub> module with 1,3-dimethoxybenzene and a <i>meta-</i>tyrosine derivative. The products, [<s"],"journal":["Journal of the American Chemical Society"],"pubmed_title":["Sequential Ir/Cu-Mediated Method for the <i>Meta</i>-Selective C-H Radiofluorination of (Hetero)Arenes."],"pmcid":["PMC8832069"],"funding_grant_id":["F32GM136022","F32 GM136022","R01 EB021155","R01EB021155"],"pubmed_authors":["Scott PJH","Wright JS","Sharninghausen LS","Sanford MS","Preshlock S","Brooks AF"],"additional_accession":[]},"is_claimable":false,"name":"Sequential Ir/Cu-Mediated Method for the <i>Meta</i>-Selective C-H Radiofluorination of (Hetero)Arenes.","description":"This article describes a sequential Ir/Cu-mediated process for the <i>meta-</i>selective C-H radiofluorination of (hetero)arene substrates. In the first step, Ir-catalyzed C(sp<sup>2</sup>)-H borylation affords (hetero)aryl pinacolboronate (BPin) esters. The intermediate organoboronates are then directly subjected to copper-mediated radiofluorination with [<sup>18</sup>F]tetrabutylammonium fluoride to afford fluorine-18 labeled (hetero)arenes in high radiochemical yield and radiochemical purity. This entire process is performed on a benchtop without Schlenk or glovebox techniques and circumvents the need to isolate (hetero)aryl boronate esters. The reaction was automated on a TracerLab FX<sub>FN</sub> module with 1,3-dimethoxybenzene and a <i>meta-</i>tyrosine derivative. The products, [<s","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 May","modification":"2025-04-04T21:32:35.386Z","creation":"2025-04-04T21:32:35.386Z"},"accession":"S-EPMC8832069","cross_references":{"pubmed":["33914521"],"doi":["10.1021/jacs.1c00523"]}}