biostudies-literatureQian CNCI NIH HHS181-189https://www.ebi.ac.uk/biostudies/studies/S-EPMC8832285biostudies-literatureUnknown530The ETS family of proteins consists of 28 transcription factors, many of which play critical roles in both normal tissue development and homeostasis and have been implicated in development and progression of a variety of cancers. In prostate cancer, gene fusion and overexpression of ETS factors ERG, FLI1, ETV1, ETV4 and ETV5 have been found in half of prostate cancer patients in Caucasian men and define the largest genetic subtype of prostate cancer. This review summarizes the data on the discovery, modeling, molecular taxonomy, lineage plasticity and therapeutic targeting of ETS family members in prostate cancer.Cancer lettersETS factors in prostate cancer.PMC8832285P50 CA092629U54 CA224079P30 CA008748K08 CA140946R01 CA208100U01 CA224044R01 CA193837Qian CLi DChen YfalseETS factors in prostate cancer.The ETS family of proteins consists of 28 transcription factors, many of which play critical roles in both normal tissue development and homeostasis and have been implicated in development and progression of a variety of cancers. In prostate cancer, gene fusion and overexpression of ETS factors ERG, FLI1, ETV1, ETV4 and ETV5 have been found in half of prostate cancer patients in Caucasian men and define the largest genetic subtype of prostate cancer. This review summarizes the data on the discovery, modeling, molecular taxonomy, lineage plasticity and therapeutic targeting of ETS family members in prostate cancer.2022-01-01T00:00:00Z2022 Apr2025-04-26T13:15:04.254Z2025-04-06T14:09:24.642ZS-EPMC88322853503358910.1016/j.canlet.2022.01.009