{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(2)"],"submitter":["He Y"],"pubmed_abstract":["Nucleoporin 37 kDa (NUP37), a member of the nucleoporin family, has been reported to regulate the proliferation and apoptosis of several tumor types. However, its role in the tumor immune microenvironment is unclear. Here, we evaluated the expression, methylation, copy number alteration, and prognostic significance of NUP37 using RNA-seq and clinical data from The Cancer Genome Atlas. We observed higher expression of NUP37 in 28 of 29 tumor types, and high NUP37 expression predicted worse survival status of patients in 15 tumors. Using data from the cBioportal database, we described the gene variation of NUP37 in glioma and pan-cancer. We further assessed the role of NUP37 in the tumor immune microenvironment using immune infiltration data. NUP37 expression was positively associated with t"],"journal":["Aging"],"pagination":["1033-1047"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8833130"],"repository":["biostudies-literature"],"pubmed_title":["Pan-cancer analysis reveals NUP37 as a prognostic biomarker correlated with the immunosuppressive microenvironment in glioma."],"pmcid":["PMC8833130"],"pubmed_authors":["Zhang G","Wen Y","Shen L","Li J","Li Z","He Y","Fei W","Wang F","Zhou H"],"additional_accession":[]},"is_claimable":false,"name":"Pan-cancer analysis reveals NUP37 as a prognostic biomarker correlated with the immunosuppressive microenvironment in glioma.","description":"Nucleoporin 37 kDa (NUP37), a member of the nucleoporin family, has been reported to regulate the proliferation and apoptosis of several tumor types. However, its role in the tumor immune microenvironment is unclear. Here, we evaluated the expression, methylation, copy number alteration, and prognostic significance of NUP37 using RNA-seq and clinical data from The Cancer Genome Atlas. We observed higher expression of NUP37 in 28 of 29 tumor types, and high NUP37 expression predicted worse survival status of patients in 15 tumors. Using data from the cBioportal database, we described the gene variation of NUP37 in glioma and pan-cancer. We further assessed the role of NUP37 in the tumor immune microenvironment using immune infiltration data. NUP37 expression was positively associated with t","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-04-18T20:23:19.845Z","creation":"2025-04-07T08:20:49.119Z"},"accession":"S-EPMC8833130","cross_references":{"pubmed":["35093934"],"doi":["10.18632/aging.203862"]}}