biostudies-literatureMakinen LWaldemar von Frenckells stiftelseMedicinska Understödsföreningen Liv och HälsaSigrid Jusélius FoundationCancer Foundations FinlandCancer Foundation Finland sr525https://www.ebi.ac.uk/biostudies/studies/S-EPMC8833348biostudies-literatureUnknown14(3)Pancreatic ductal adenocarcinoma (PDAC) is a silent killer, often diagnosed late. However, it is also dishearteningly resistant to nearly all forms of treatment. New therapies are urgently needed, and with the advent of organoid culture for pancreatic cancer, an increasing number of innovative approaches are being tested. Organoids can be derived within a short enough time window to allow testing of several anticancer agents, which opens up the possibility for functional precision medicine for pancreatic cancer. At the same time, organoid model systems are being refined to better mimic the cancer, for example, by incorporation of components of the tumor microenvironment. We review some of the latest developments in pancreatic cancer organoid research and in novel treatment design. We also CancersPancreatic Cancer Organoids in the Field of Precision Medicine: A Review of Literature and Experience on Drug Sensitivity Testing with Multiple Readouts and Synergy Scoring.PMC883334820192017-202121007520212018-2021Seppanen HWennerberg KHagstrom JVaha-Koskela MMustonen HPuolakkainen PMakinen LJuusola MfalsePancreatic Cancer Organoids in the Field of Precision Medicine: A Review of Literature and Experience on Drug Sensitivity Testing with Multiple Readouts and Synergy Scoring.Pancreatic ductal adenocarcinoma (PDAC) is a silent killer, often diagnosed late. However, it is also dishearteningly resistant to nearly all forms of treatment. New therapies are urgently needed, and with the advent of organoid culture for pancreatic cancer, an increasing number of innovative approaches are being tested. Organoids can be derived within a short enough time window to allow testing of several anticancer agents, which opens up the possibility for functional precision medicine for pancreatic cancer. At the same time, organoid model systems are being refined to better mimic the cancer, for example, by incorporation of components of the tumor microenvironment. We review some of the latest developments in pancreatic cancer organoid research and in novel treatment design. We also 2022-01-01T00:00:00Z2022 Jan2025-06-01T01:33:13.28Z2024-11-14T00:28:08.195ZS-EPMC88333483515879410.3390/cancers14030525