{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(3)"],"submitter":["Maier J"],"pubmed_abstract":["Richter syndrome (RS) is defined as the transformation of chronic lymphocytic leukemia (CLL) into an aggressive lymphoma, mostly diffuse large B-cell lymphoma (DLBCL). Despite intensive therapy, patients with RS have an unfavorable clinical outcome. The detailed pathobiology of Richter transformation still needs to be elucidated. Here, we report high mRNA and protein levels of <i>CARD9</i> in the RS cell line U-RT1. Co-immunoprecipitation revealed the assembly of a CBM complex using CARD9 instead of CARD11. CARD9 is known to be an activator of NF-кB signaling in myeloid cells. U-RT1 Western blot analyses showed phosphorylation of IκB as well as IKK, indicating a constitutively active canonical NF-кB pathway. This was further supported by the significant reduction in cell viability and CYLD"],"journal":["Cancers"],"pagination":["531"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8833648"],"repository":["biostudies-literature"],"pubmed_title":["CARD9 Forms an Alternative CBM Complex in Richter Syndrome."],"pmcid":["PMC8833648"],"pubmed_authors":["Maier J","Lechel A","Barth TFE","Moller P","Mellert K","Marienfeld R"],"additional_accession":[]},"is_claimable":false,"name":"CARD9 Forms an Alternative CBM Complex in Richter Syndrome.","description":"Richter syndrome (RS) is defined as the transformation of chronic lymphocytic leukemia (CLL) into an aggressive lymphoma, mostly diffuse large B-cell lymphoma (DLBCL). Despite intensive therapy, patients with RS have an unfavorable clinical outcome. The detailed pathobiology of Richter transformation still needs to be elucidated. Here, we report high mRNA and protein levels of <i>CARD9</i> in the RS cell line U-RT1. Co-immunoprecipitation revealed the assembly of a CBM complex using CARD9 instead of CARD11. CARD9 is known to be an activator of NF-кB signaling in myeloid cells. U-RT1 Western blot analyses showed phosphorylation of IκB as well as IKK, indicating a constitutively active canonical NF-кB pathway. This was further supported by the significant reduction in cell viability and CYLD","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2026-04-08T17:24:55.116Z","creation":"2025-04-19T22:37:17.188Z"},"accession":"S-EPMC8833648","cross_references":{"pubmed":["35158799"],"doi":["10.3390/cancers14030531"]}}