{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Costantini S"],"funding":["Italian Ministry of Health – Ricerca Corrente Funds—Istituto Nazionale Tumori G. Pascale-Progetti"],"pagination":["646"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8833666"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(3)"],"pubmed_abstract":["Triple negative breast cancer (TNBC) is a heterogeneous group of tumors with early relapse, poor overall survival, and lack of effective treatments. Hence, new prognostic biomarkers and therapeutic targets are needed. The expression profile of all twenty-five human selenoproteins was analyzed in TNBC by a systematic approach.In silicoanalysis was performed on publicly available mRNA expression datasets (Cancer Cell Line Encyclopedia, CCLE and Library of Integrated Network-based Cellular Signatures, LINCS). Reverse transcription quantitative PCR analysis evaluated selenoprotein mRNA expression in TNBC versus non-TNBC and normal breast cells, and in TNBC tissues versus normal counterparts. Immunohistochemistry was employed to study selenoproteins in TNBC tissues. STRING and Cytoscape tools w"],"journal":["Cancers"],"pubmed_title":["An Integrated In Silico, In Vitro and Tumor Tissues Study Identified Selenoprotein S (SELENOS) and Valosin-Containing Protein (VCP/p97) as Novel Potential Associated Prognostic Biomarkers in Triple Negative Breast Cancer."],"pmcid":["PMC8833666"],"funding_grant_id":["B61G18000470007","Project Code: 24190","M3/6 and M2/5"],"pubmed_authors":["Fratelli M","Capone F","Bagnara P","Ciliberto G","Sorice A","Zito Marino F","Costantini S","Polo A","Accardo M","Budillon A","Lombardi R","Orditura M","Amato M"],"additional_accession":[]},"is_claimable":false,"name":"An Integrated In Silico, In Vitro and Tumor Tissues Study Identified Selenoprotein S (SELENOS) and Valosin-Containing Protein (VCP/p97) as Novel Potential Associated Prognostic Biomarkers in Triple Negative Breast Cancer.","description":"Triple negative breast cancer (TNBC) is a heterogeneous group of tumors with early relapse, poor overall survival, and lack of effective treatments. Hence, new prognostic biomarkers and therapeutic targets are needed. The expression profile of all twenty-five human selenoproteins was analyzed in TNBC by a systematic approach.In silicoanalysis was performed on publicly available mRNA expression datasets (Cancer Cell Line Encyclopedia, CCLE and Library of Integrated Network-based Cellular Signatures, LINCS). Reverse transcription quantitative PCR analysis evaluated selenoprotein mRNA expression in TNBC versus non-TNBC and normal breast cells, and in TNBC tissues versus normal counterparts. Immunohistochemistry was employed to study selenoproteins in TNBC tissues. STRING and Cytoscape tools w","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-04-26T03:57:15.035Z","creation":"2024-11-14T08:13:31.477Z"},"accession":"S-EPMC8833666","cross_references":{"pubmed":["35158912"],"doi":["10.3390/cancers14030646"]}}