biostudies-literatureBerois NPrograma Grupos de Investigación, CSIC, Universidad de la República, Uruguay645https://www.ebi.ac.uk/biostudies/studies/S-EPMC8833780biostudies-literatureUnknown14(3)Aberrant glycosylation is a hallmark of cancer and can lead to changes that influence tumor behavior. Glycans can serve as a source of novel clinical biomarker developments, providing a set of specific targets for therapeutic intervention. Different mechanisms of aberrant glycosylation lead to the formation of tumor-associated carbohydrate antigens (TACAs) suitable for selective cancer-targeting therapy. The best characterized TACAs are truncated O-glycans (Tn, TF, and sialyl-Tn antigens), gangliosides (GD2, GD3, GM2, GM3, fucosyl-GM1), globo-serie glycans (Globo-H, SSEA-3, SSEA-4), Lewis antigens, and polysialic acid. In this review, we analyze strategies for cancer immunotherapy targeting TACAs, including different antibody developments, the production of vaccines, and the generation of CancersTargeting Tumor Glycans for Cancer Therapy: Successes, Limitations, and Perspectives.PMC8833780COF 03/11number 908Berois NPittini AOsinaga EfalseTargeting Tumor Glycans for Cancer Therapy: Successes, Limitations, and Perspectives.Aberrant glycosylation is a hallmark of cancer and can lead to changes that influence tumor behavior. Glycans can serve as a source of novel clinical biomarker developments, providing a set of specific targets for therapeutic intervention. Different mechanisms of aberrant glycosylation lead to the formation of tumor-associated carbohydrate antigens (TACAs) suitable for selective cancer-targeting therapy. The best characterized TACAs are truncated O-glycans (Tn, TF, and sialyl-Tn antigens), gangliosides (GD2, GD3, GM2, GM3, fucosyl-GM1), globo-serie glycans (Globo-H, SSEA-3, SSEA-4), Lewis antigens, and polysialic acid. In this review, we analyze strategies for cancer immunotherapy targeting TACAs, including different antibody developments, the production of vaccines, and the generation of 2022-01-01T00:00:00Z2022 Jan2025-04-04T08:01:35.873Z2025-04-04T08:01:35.873ZS-EPMC88337803515891510.3390/cancers14030645