{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["23(3)"],"submitter":["Porro B"],"pubmed_abstract":["Clinical data indicate that low circulating l-homoarginine (HArg) concentrations are associated with cardiovascular (CV) disease, CV mortality, and all-cause mortality. A high number of LC-based analytical methods for the quantification of HArg, in combination with the l-arginine (Arg)-related pathway metabolites, have been reported. However, these methods usually consider a limited panel of analytes. Thus, in order to achieve a comprehensive picture of the Arg metabolism, we described an improved targeted metabolomic approach based on a multiple reaction monitoring (MRM) mass spectrometry method for the simultaneous quantification of the Arg/nitric oxide (NO) pathway metabolites. This methodology was then employed to quantify the plasma concentrations of these analytes in a cohort of indi"],"journal":["International journal of molecular sciences"],"pagination":["1136"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8835333"],"repository":["biostudies-literature"],"pubmed_title":["An Optimized MRM-Based Workflow of the l-Arginine/Nitric Oxide Pathway Metabolites Revealed Disease- and Sex-Related Differences in the Cardiovascular Field."],"pmcid":["PMC8835333"],"pubmed_authors":["Cosentino N","Conte E","Cavalca V","Capra N","Porro B","Banfi C","Eligini S"],"additional_accession":[]},"is_claimable":false,"name":"An Optimized MRM-Based Workflow of the l-Arginine/Nitric Oxide Pathway Metabolites Revealed Disease- and Sex-Related Differences in the Cardiovascular Field.","description":"Clinical data indicate that low circulating l-homoarginine (HArg) concentrations are associated with cardiovascular (CV) disease, CV mortality, and all-cause mortality. A high number of LC-based analytical methods for the quantification of HArg, in combination with the l-arginine (Arg)-related pathway metabolites, have been reported. However, these methods usually consider a limited panel of analytes. Thus, in order to achieve a comprehensive picture of the Arg metabolism, we described an improved targeted metabolomic approach based on a multiple reaction monitoring (MRM) mass spectrometry method for the simultaneous quantification of the Arg/nitric oxide (NO) pathway metabolites. This methodology was then employed to quantify the plasma concentrations of these analytes in a cohort of indi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-05-29T21:04:19.582Z","creation":"2025-05-29T21:04:19.582Z"},"accession":"S-EPMC8835333","cross_references":{"pubmed":["35163055"],"doi":["10.3390/ijms23031136"]}}