biostudies-literatureHood RBNIEHS NIH HHSe191https://www.ebi.ac.uk/biostudies/studies/S-EPMC8835541biostudies-literatureUnknown6(1)<h4>Background</h4>Both acute and chronic exposure to fine particulate matter (PM_2.5) have been linked to negative health outcomes. Studies have used metabolomics to describe the biological pathways linking PM_2.5 with disease but have focused on a single exposure window. We compared alterations in the serum metabolome following various short- and long-term PM_2.5 exposures.<h4>Methods</h4>Participants were women undergoing <i>in vitro</i> fertilization at a New England fertility clinic (n = 200). Women provided their residential address and provided a blood sample during controlled ovarian stimulation. PM_2.5 exposure was estimated in the 1, 2, and 3 days, 2 weeks, and 3 months prior to blood collection using a validated spatiotemporal model. We utEnvironmental epidemiology (Philadelphia, Pa.)Length of PM_2.5 exposure and alterations in the serum metabolome among women undergoing infertility treatment.PMC8835541P30 ES000002R01 ES009718R00 ES026648R01 ES022955P30 ES019776Hood RBLiang DTang ZKloog IGaskins AJSchwartz JLaden FJones DfalseLength of PM_2.5 exposure and alterations in the serum metabolome among women undergoing infertility treatment.<h4>Background</h4>Both acute and chronic exposure to fine particulate matter (PM_2.5) have been linked to negative health outcomes. Studies have used metabolomics to describe the biological pathways linking PM_2.5 with disease but have focused on a single exposure window. We compared alterations in the serum metabolome following various short- and long-term PM_2.5 exposures.<h4>Methods</h4>Participants were women undergoing <i>in vitro</i> fertilization at a New England fertility clinic (n = 200). Women provided their residential address and provided a blood sample during controlled ovarian stimulation. PM_2.5 exposure was estimated in the 1, 2, and 3 days, 2 weeks, and 3 months prior to blood collection using a validated spatiotemporal model. We ut2022-01-01T00:00:00Z2022 Feb2025-04-04T20:23:39.232Z2025-04-04T20:23:39.232ZS-EPMC88355413516966910.1097/EE9.0000000000000191