biostudies-literatureVanoli JNIEHS NIH HHSNIMHD NIH HHSe181https://www.ebi.ac.uk/biostudies/studies/S-EPMC8835545biostudies-literatureUnknown6(1)<h4>Background</h4>Inconsistent evidence has assessed the impact of air pollution exposure on children's growth trajectories. We investigated the role of 90-day average postnatal fine particulate matter (PM_2.5) exposures by estimating the magnitude of effects at different ages, and the change in child weight trajectory by categories of exposure.<h4>Methods</h4>We obtained weight values from electronic health records at each hospital visit (males = 1859, females = 1601) from birth to 6 years old children recruited into the Boston-based Children's HealthWatch cohort (2009-2014). We applied mixed models, adjusting for individual and maternal confounders using (1) varying-coefficient models allowing for smooth non-linear interaction between age and PM_2.5, (2) factor-smootEnvironmental epidemiology (Philadelphia, Pa.)Postnatal exposure to PM_2.5 and weight trajectories in early childhood.PMC8835545P30 ES000002P50 MD010428Kloog IMassaro MAEttinger de Cuba SVanoli JZanobetti APoblacion ASchwartz JCoull BALaden FFabian PMCarnes FBellocco RfalsePostnatal exposure to PM_2.5 and weight trajectories in early childhood.<h4>Background</h4>Inconsistent evidence has assessed the impact of air pollution exposure on children's growth trajectories. We investigated the role of 90-day average postnatal fine particulate matter (PM_2.5) exposures by estimating the magnitude of effects at different ages, and the change in child weight trajectory by categories of exposure.<h4>Methods</h4>We obtained weight values from electronic health records at each hospital visit (males = 1859, females = 1601) from birth to 6 years old children recruited into the Boston-based Children's HealthWatch cohort (2009-2014). We applied mixed models, adjusting for individual and maternal confounders using (1) varying-coefficient models allowing for smooth non-linear interaction between age and PM_2.5, (2) factor-smoot2022-01-01T00:00:00Z2022 Feb2025-04-06T19:26:10.089Z2025-04-06T19:26:10.089ZS-EPMC88355453516966110.1097/EE9.0000000000000181