{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["41(7)"],"submitter":["Nan G"],"pubmed_abstract":["Though the great success of paclitaxel, the variable response of patients to the drug limits its clinical utility and the precise mechanisms underlying the variable response to paclitaxel remain largely unknown. This study aims to verify the role and the underlying mechanisms of CD147 in paclitaxel resistance. Immunostaining was used to analyze human non-small-cell lung cancer (NSCLC) and ovarian cancer tissues. RNA-sequencing was used to identify downstream effectors. Annexin V-FITC/propidium iodide and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining were used to detect apoptosis. Co-immunoprecipitation (Co-IP), fluorescence resonance energy transfer (FRET) and surface plasmon resonance (SPR) were performed to determine protein interactions. Fluorescence reco"],"journal":["Oncogene"],"pagination":["983-996"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8837534"],"repository":["biostudies-literature"],"pubmed_title":["CD147 supports paclitaxel resistance via interacting with RanBP1."],"pmcid":["PMC8837534"],"pubmed_authors":["Lin P","Wang B","Fu X","Guo T","Zhao SH","Chao D","Cui HY","Wang WJ","Sun XX","Tian RF","Wang SJ","Wang T","Nan G","Chen X","Chen ZN"],"additional_accession":[]},"is_claimable":false,"name":"CD147 supports paclitaxel resistance via interacting with RanBP1.","description":"Though the great success of paclitaxel, the variable response of patients to the drug limits its clinical utility and the precise mechanisms underlying the variable response to paclitaxel remain largely unknown. This study aims to verify the role and the underlying mechanisms of CD147 in paclitaxel resistance. Immunostaining was used to analyze human non-small-cell lung cancer (NSCLC) and ovarian cancer tissues. RNA-sequencing was used to identify downstream effectors. Annexin V-FITC/propidium iodide and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining were used to detect apoptosis. Co-immunoprecipitation (Co-IP), fluorescence resonance energy transfer (FRET) and surface plasmon resonance (SPR) were performed to determine protein interactions. Fluorescence reco","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-05T13:08:10.743Z","creation":"2025-04-05T13:08:10.743Z"},"accession":"S-EPMC8837534","cross_references":{"pubmed":["34974521"],"doi":["10.1038/s41388-021-02143-3"]}}