biostudies-literatureUnknown24(1)Sagard JAlfred Österlunds StiftelseStiftelsen Professor Nanna Svartz FondGrants from the Swedish government to researchers in public health careReumatikerförbundetSkånes universitetssjukhusKock FoundationAnna-Greta Crafoords stiftelseHedlund FoundationLundgren FoundationLund University<h4>Background</h4>Based on clinical and genetic associations, axial spondyloarthritis (axSpA) and inflammatory bowel disease (IBD) are suspected to have a linked pathogenesis. Gut dysbiosis, intrinsic to IBD, has also been observed in axSpA. It is, however, not established to what degree gut dysbiosis is associated with axSpA disease severity. The objective of this study was to compare gut dysbiosis frequency between controls, non-radiographic axial spondyloarthritis (nr-axSpA), and ankylosing spondylitis (AS) patients and investigate whether gut dysbiosis is cross-sectionally associated with axSpA disease activity, physical function, mobility, or pain.<h4>Methods</h4>Gut dysbiosis was assessed by 16SrRNA analysis of feces from 44/88 nr-axSpA/AS patients (ASAS/mNY criteria) without inflamArthritis research & therapy42https://www.ebi.ac.uk/biostudies/studies/S-EPMC8840679biostudies-literatureGut dysbiosis associated with worse disease activity and physical function in axial spondyloarthritis.PMC8840679Geijer MAndreasson KKristensen LESagard JOlofsson TMarsal JLindqvist EWallman JKMogard EfalseGut dysbiosis associated with worse disease activity and physical function in axial spondyloarthritis.<h4>Background</h4>Based on clinical and genetic associations, axial spondyloarthritis (axSpA) and inflammatory bowel disease (IBD) are suspected to have a linked pathogenesis. Gut dysbiosis, intrinsic to IBD, has also been observed in axSpA. It is, however, not established to what degree gut dysbiosis is associated with axSpA disease severity. The objective of this study was to compare gut dysbiosis frequency between controls, non-radiographic axial spondyloarthritis (nr-axSpA), and ankylosing spondylitis (AS) patients and investigate whether gut dysbiosis is cross-sectionally associated with axSpA disease activity, physical function, mobility, or pain.<h4>Methods</h4>Gut dysbiosis was assessed by 16SrRNA analysis of feces from 44/88 nr-axSpA/AS patients (ASAS/mNY criteria) without inflam2022-01-01T00:00:00Z2022 Feb2026-06-03T10:25:04.813Z2025-04-06T15:51:20.463ZS-EPMC88406793515135710.1186/s13075-022-02733-w