{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Thorseth ML"],"pubmed_abstract":["Increased remodeling of the extracellular matrix in malignant tumors has been shown to correlate with tumor aggressiveness and a poor prognosis. This remodeling involves degradation of the original extracellular matrix (ECM) and deposition of a new tumor-supporting ECM. The main constituent of the ECM is collagen and collagen turnover mainly occurs in a sequential manner, where initial proteolytic cleavage of the insoluble fibers is followed by cellular internalization of large well-defined collagen fragments for lysosomal degradation. However, despite extensive research in the field, a lack of consensus on which cell types within the tumor microenvironment express the involved proteases still exists. Furthermore, the relative contribution of different cell types to collagen internalizatio"],"journal":["Matrix biology plus"],"pagination":["100101"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8841889"],"repository":["biostudies-literature"],"pubmed_title":["Uncovering mediators of collagen degradation in the tumor microenvironment."],"pmcid":["PMC8841889"],"pubmed_authors":["Jurgensen HJ","Carretta M","Behrendt N","Willumsen N","Engelholm LH","Thorseth ML","Jensen C","Molgaard K","Madsen DH"],"additional_accession":[]},"is_claimable":false,"name":"Uncovering mediators of collagen degradation in the tumor microenvironment.","description":"Increased remodeling of the extracellular matrix in malignant tumors has been shown to correlate with tumor aggressiveness and a poor prognosis. This remodeling involves degradation of the original extracellular matrix (ECM) and deposition of a new tumor-supporting ECM. The main constituent of the ECM is collagen and collagen turnover mainly occurs in a sequential manner, where initial proteolytic cleavage of the insoluble fibers is followed by cellular internalization of large well-defined collagen fragments for lysosomal degradation. However, despite extensive research in the field, a lack of consensus on which cell types within the tumor microenvironment express the involved proteases still exists. Furthermore, the relative contribution of different cell types to collagen internalizatio","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-04T14:50:17.673Z","creation":"2025-04-04T14:50:17.673Z"},"accession":"S-EPMC8841889","cross_references":{"pubmed":["35198964"],"doi":["10.1016/j.mbplus.2022.100101"]}}