biostudies-literatureUnknown13Thorseth MLIncreased remodeling of the extracellular matrix in malignant tumors has been shown to correlate with tumor aggressiveness and a poor prognosis. This remodeling involves degradation of the original extracellular matrix (ECM) and deposition of a new tumor-supporting ECM. The main constituent of the ECM is collagen and collagen turnover mainly occurs in a sequential manner, where initial proteolytic cleavage of the insoluble fibers is followed by cellular internalization of large well-defined collagen fragments for lysosomal degradation. However, despite extensive research in the field, a lack of consensus on which cell types within the tumor microenvironment express the involved proteases still exists. Furthermore, the relative contribution of different cell types to collagen internalizatioMatrix biology plus100101https://www.ebi.ac.uk/biostudies/studies/S-EPMC8841889biostudies-literatureUncovering mediators of collagen degradation in the tumor microenvironment.PMC8841889Jurgensen HJCarretta MBehrendt NWillumsen NEngelholm LHThorseth MLJensen CMolgaard KMadsen DHfalseUncovering mediators of collagen degradation in the tumor microenvironment.Increased remodeling of the extracellular matrix in malignant tumors has been shown to correlate with tumor aggressiveness and a poor prognosis. This remodeling involves degradation of the original extracellular matrix (ECM) and deposition of a new tumor-supporting ECM. The main constituent of the ECM is collagen and collagen turnover mainly occurs in a sequential manner, where initial proteolytic cleavage of the insoluble fibers is followed by cellular internalization of large well-defined collagen fragments for lysosomal degradation. However, despite extensive research in the field, a lack of consensus on which cell types within the tumor microenvironment express the involved proteases still exists. Furthermore, the relative contribution of different cell types to collagen internalizatio2022-01-01T00:00:00Z2022 Feb2025-04-04T14:50:17.673Z2025-04-04T14:50:17.673ZS-EPMC88418893519896410.1016/j.mbplus.2022.100101