{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hebestreit H"],"funding":["German Innovationsfond","Universitätsklinikum Würzburg"],"pagination":["47"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8842899"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["<h4>Background</h4>In individuals suffering from a rare disease the diagnostic process and the confirmation of a final diagnosis often extends over many years. Factors contributing to delayed diagnosis include health care professionals' limited knowledge of rare diseases and frequent (co-)occurrence of mental disorders that may complicate and delay the diagnostic process. The ZSE-DUO study aims to assess the benefits of a combination of a physician focusing on somatic aspects with a mental health expert working side by side as a tandem in the diagnostic process.<h4>Study design</h4>This multi-center, prospective controlled study has a two-phase cohort design.<h4>Methods</h4>Two cohorts of 682 patients each are sequentially recruited from 11 university-based German Centers for Rare Diseases"],"journal":["Orphanet journal of rare diseases"],"pubmed_title":["Dual guidance structure for evaluation of patients with unclear diagnosis in centers for rare diseases (ZSE-DUO): study protocol for a controlled multi-center cohort study."],"pmcid":["PMC8842899"],"funding_grant_id":["01NVF17031"],"pubmed_authors":["Heuschmann P","Frommer J","Hennermann J","Weiler C","Zeidler C","Ott S","Haas A","Quitmann J","Pfister L","Hebestreit H","Haas K","Blomeke J","Spangenberger A","Glode A","Latzko P","Berger A","Babka C","Dieris-Hirche J","Zenker K","Schippers C","Greger H","Selig U","Schulz JB","Bohm L","Brinkmann F","Walter S","Romanos M","Hilbig B","Volk D","Debatin KM","Krassort H","Schaubert K","Schoels L","Berneburg M","Herpertz S","Steinbuchel T","Gundel H","Musacchio T","Stosser S","de Zwaan M","de Greck M","Rieß O","Celiker M","Imhof C","Lucke T","Tuscher O","Britz V","Ungethum K","Rampp C","Zhang KD","Holthofer L","Brandstetter L","Vogel M","Eymann J","Schneider S","Grasemann C","Deibele A","Kratz C","Petermann-Meyer A","Kassubek J","Dillmann-Jehn K","Junne F","Loew T","Herrmann-Werner A","Suchant S","Koschitzki KT","Godecke V","Mundlos C","Ettinger M","Schmidt A","Vollmuth C","Muller S","Jacob T","Bullinger M","Bottger B","Zajt KK","Maisch T","Nießen M","Meyer T","Schubert K","Gabrian M","Haisch L","ZSE-DUO working group","Graessner H","Zipfel S","Braun B","Rutsch F","Kuhn J","Kristensen K","Grauer E","Haase M","Krauth C","Nohre M","Sroka A","Cario H","Deckert J","Akkaya F","Barlescu L","Dos Santos IM","Warrings B","Barsch-Michelmann A","Kropff B","Mohnike K","Ertl M","Wagner TOF","Ludolph AC","Witt S","Heuft G","Held M","Richter A","Nanciu AN","Pfeifer-Duck C","Zeltner L","Kick L","Karl S","Hett J","Schweiger S","Papagianni A","Heinrich I","Lapstich AM","Monninger M","Volnov S","Piduhn LS","Bergbreiter A","Schwalba M","Lorenz D"],"additional_accession":[]},"is_claimable":false,"name":"Dual guidance structure for evaluation of patients with unclear diagnosis in centers for rare diseases (ZSE-DUO): study protocol for a controlled multi-center cohort study.","description":"<h4>Background</h4>In individuals suffering from a rare disease the diagnostic process and the confirmation of a final diagnosis often extends over many years. Factors contributing to delayed diagnosis include health care professionals' limited knowledge of rare diseases and frequent (co-)occurrence of mental disorders that may complicate and delay the diagnostic process. The ZSE-DUO study aims to assess the benefits of a combination of a physician focusing on somatic aspects with a mental health expert working side by side as a tandem in the diagnostic process.<h4>Study design</h4>This multi-center, prospective controlled study has a two-phase cohort design.<h4>Methods</h4>Two cohorts of 682 patients each are sequentially recruited from 11 university-based German Centers for Rare Diseases","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-26T09:46:33.249Z","creation":"2024-11-19T21:52:44.667Z"},"accession":"S-EPMC8842899","cross_references":{"pubmed":["35164804"],"doi":["10.1186/s13023-022-02176-1"]}}