{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ji HB"],"funding":["Ministry of Trade, Industry and Energy","SNUH Research Fund","Basic Science Research Program through the National Research Foundation of Korea","Korea Institute for Advancement of Technology (KIAT) through the International Cooperative R&D Program","Ministry of Science, ICT & Future Planning"],"pagination":["489-498"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8843219"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(1)"],"pubmed_abstract":["For the prolonged, controlled delivery of systemic drugs, we propose an implantable drug-delivery chip (DDC) embedded with pairs of a microchannel and drug-reservoir serving as a drug diffusion barrier and depot, respectively. We pursued a DDC for dual drugs: a main-purpose drug, diclofenac (DF), for systemic exposure, and an antifibrotic drug, tranilast (TR), for local delivery. Thus, the problematic fibrotic tissue formation around the implanted device could be diminished, thereby less hindrance in systemic exposure of DF released from the DDC. First, we separately prepared DDCs for DF or TR delivery, and sought to find a proper microchannel length for a rapid onset and sustained pattern of drug release, as well as the required drug dose. Then, two distinct DDCs for DF and TR delivery, r"],"journal":["Drug delivery"],"pubmed_title":["Microchannel-embedded implantable device with fibrosis suppression for prolonged controlled drug delivery."],"pmcid":["PMC8843219"],"funding_grant_id":["190","20","NRF-"],"pubmed_authors":["Lee C","Kim CR","Hong JY","Choy YB","Ji HB","Kim SN","Kim MJ","Min CH","Han JH"],"additional_accession":[]},"is_claimable":false,"name":"Microchannel-embedded implantable device with fibrosis suppression for prolonged controlled drug delivery.","description":"For the prolonged, controlled delivery of systemic drugs, we propose an implantable drug-delivery chip (DDC) embedded with pairs of a microchannel and drug-reservoir serving as a drug diffusion barrier and depot, respectively. We pursued a DDC for dual drugs: a main-purpose drug, diclofenac (DF), for systemic exposure, and an antifibrotic drug, tranilast (TR), for local delivery. Thus, the problematic fibrotic tissue formation around the implanted device could be diminished, thereby less hindrance in systemic exposure of DF released from the DDC. First, we separately prepared DDCs for DF or TR delivery, and sought to find a proper microchannel length for a rapid onset and sustained pattern of drug release, as well as the required drug dose. Then, two distinct DDCs for DF and TR delivery, r","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-18T20:24:15.936Z","creation":"2025-04-07T08:23:04.356Z"},"accession":"S-EPMC8843219","cross_references":{"pubmed":["35147052"],"doi":["10.1080/10717544.2022.2032873"]}}