{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li Z"],"funding":["Shandong Province Key Research and Development Plan"],"pagination":["7421265"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8843792"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2022"],"pubmed_abstract":["<h4>Objective</h4>Immune imbalance and the inflammatory response are associated with atherosclerosis (AS) progression. <i>Astragali Radix</i> and <i>Coptis Rhizoma</i> (ARCR) are an ancient and classic herb pair that is used in herbal medicines for the treatment of coronary heart disease. We focused on the effects and mechanisms of the ARCR herb pair attenuation of atherosclerosis in apolipoprotein E knockout (ApoE-/-) mice.<h4>Methods</h4>ApoE-/- mice were fed a high-fat diet for 12 weeks to establish a model of AS. The ApoE-/- mice were randomly divided into a model group, simvastatin group (Simva), <i>Astragali Radix</i> group (AR), <i>Coptis Rhizoma</i> group (CR), <i>Astragali Radix-Coptis Rhizoma</i> group (ARCR), and <i>Astragali Radix-Coptis Rhizoma</i> + signal transducer and acti"],"journal":["Evidence-based complementary and alternative medicine : eCAM"],"pubmed_title":["<i>Astragali Radix-Coptis Rhizoma</i> Herb Pair Attenuates Atherosclerosis in ApoE-/- Mice by Regulating the M1/M2 and Th1/Th2 Immune Balance and Activating the STAT6 Signaling Pathway."],"pmcid":["PMC8843792"],"funding_grant_id":["2019GSF108024"],"pubmed_authors":["Jiang Y","Li X","Li Z","Zhang Y","Wu S","Ma D","Wang Y","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"<i>Astragali Radix-Coptis Rhizoma</i> Herb Pair Attenuates Atherosclerosis in ApoE-/- Mice by Regulating the M1/M2 and Th1/Th2 Immune Balance and Activating the STAT6 Signaling Pathway.","description":"<h4>Objective</h4>Immune imbalance and the inflammatory response are associated with atherosclerosis (AS) progression. <i>Astragali Radix</i> and <i>Coptis Rhizoma</i> (ARCR) are an ancient and classic herb pair that is used in herbal medicines for the treatment of coronary heart disease. We focused on the effects and mechanisms of the ARCR herb pair attenuation of atherosclerosis in apolipoprotein E knockout (ApoE-/-) mice.<h4>Methods</h4>ApoE-/- mice were fed a high-fat diet for 12 weeks to establish a model of AS. The ApoE-/- mice were randomly divided into a model group, simvastatin group (Simva), <i>Astragali Radix</i> group (AR), <i>Coptis Rhizoma</i> group (CR), <i>Astragali Radix-Coptis Rhizoma</i> group (ARCR), and <i>Astragali Radix-Coptis Rhizoma</i> + signal transducer and acti","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-22T21:36:58.826Z","creation":"2024-11-12T21:23:51.265Z"},"accession":"S-EPMC8843792","cross_references":{"pubmed":["35178108"],"doi":["10.1155/2022/7421265"]}}