{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yan Y"],"funding":["U.S. Department of Defense","National Cancer Institute","NCI NIH HHS"],"pagination":["e2100172"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8844095"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(4)"],"pubmed_abstract":["Prostate cancer (PC) is a major health and economic problem in industrialized countries, yet our understanding of the molecular mechanisms of PC progression and drug response remains limited. Accumulating evidence showed that certain E3 ubiquitin ligases such as SIAH2, RNF7, and SPOP play important roles in PC development and progression. However, the roles and mechanisms of other E3s in PC progression remain largely unexplored. Through an integration analysis of clinical genomic and transcriptomic profiles of PC tumors, this study identified UBR5 as a top PC-relevant E3 ubiquitin ligase whose expression levels are strongly associated with PC progression and aggressiveness. BoxCar and shotgun proteomic analyses of control and UBR5-knockdown PC3 cells complementarily identified 75 UBR5-regu"],"journal":["Proteomics"],"pubmed_title":["BoxCar and shotgun proteomic analyses reveal molecular networks regulated by UBR5 in prostate cancer."],"pmcid":["PMC8844095"],"funding_grant_id":["R01 CA220327","R01CA218526","R01 CA271750","R01 CA218526","W81XWH‐18‐1‐0476"],"pubmed_authors":["Yang W","Freeman MR","Zhou B","You S","Lee YJ","Yan Y"],"additional_accession":[]},"is_claimable":false,"name":"BoxCar and shotgun proteomic analyses reveal molecular networks regulated by UBR5 in prostate cancer.","description":"Prostate cancer (PC) is a major health and economic problem in industrialized countries, yet our understanding of the molecular mechanisms of PC progression and drug response remains limited. Accumulating evidence showed that certain E3 ubiquitin ligases such as SIAH2, RNF7, and SPOP play important roles in PC development and progression. However, the roles and mechanisms of other E3s in PC progression remain largely unexplored. Through an integration analysis of clinical genomic and transcriptomic profiles of PC tumors, this study identified UBR5 as a top PC-relevant E3 ubiquitin ligase whose expression levels are strongly associated with PC progression and aggressiveness. BoxCar and shotgun proteomic analyses of control and UBR5-knockdown PC3 cells complementarily identified 75 UBR5-regu","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2026-05-31T01:00:26.21Z","creation":"2025-04-04T14:59:11.532Z"},"accession":"S-EPMC8844095","cross_references":{"pubmed":["34897998"],"doi":["10.1002/pmic.202100172"]}}