biostudies-literatureUnknown9Gutierrez AInstituto de Salud Carlos III<h4>Background</h4>Previous studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain.<h4>Methods</h4>Prospective, observational, multicenter study comparing cohorts of IBD patients from ENEIDA-registry who were born outside Spain with a cohort of native patients.<h4>Results</h4>We included 13,524 patients (1,864 immigrant and 11,660 native). The immigrants were younger (45 ± 12 vs. 54 ± 16 years, <i>p</i> < 0.001), had been diagnosed younger (31 ± 12 vs. 36 ± 15 years, <i>p</i> < 0.001), and had a shorter disease duration (14 ± 7 vs. 18 ± 8 years, <i>p</i> < 0.001) than native patients. Family history of IBD (9 vs. 14%, <i>p</i> < 0.001) and smoking (30 vs.Frontiers in medicine823900https://www.ebi.ac.uk/biostudies/studies/S-EPMC8844561biostudies-literatureImmigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients.PMC8844561Huguet JFernandez-Salazar LAlmela PBujanda LVarela PCarpio DSainz ECalvet XMerino OManosa MSese EMunoz-Villafranca COlivares DDomenech ERoldon MAguas MMorales VPerez-Calle JLIglesias EGutierrez AGinard DZapater PMunoz RVan Domselaar MBusquets DArguelles-Arias FAlcain GBermejo FVela MRiera JMartinez-Montiel MPPiqueras MBosca-Watts MGisbert JPMadero LDe Francisco RRodriguez CMancenido NRoncero OMartin-Arranz MDNavarro MSanchez-Rodriguez ELaredo VRicart EGonzalez-Vivo MHerreros BZabana YFrances RGordillo JHinojosa ELucendo AJMunoz FRivero MDe Castro LVera IArias LBarrio JMarin-Jimenez ICamps BLorente RBarreiro-de Acosta MSierra ERamos LSierra MRodriguez-Lago ISempere LfalseImmigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients.<h4>Background</h4>Previous studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain.<h4>Methods</h4>Prospective, observational, multicenter study comparing cohorts of IBD patients from ENEIDA-registry who were born outside Spain with a cohort of native patients.<h4>Results</h4>We included 13,524 patients (1,864 immigrant and 11,660 native). The immigrants were younger (45 ± 12 vs. 54 ± 16 years, <i>p</i> < 0.001), had been diagnosed younger (31 ± 12 vs. 36 ± 15 years, <i>p</i> < 0.001), and had a shorter disease duration (14 ± 7 vs. 18 ± 8 years, <i>p</i> < 0.001) than native patients. Family history of IBD (9 vs. 14%, <i>p</i> < 0.001) and smoking (30 vs.2022-01-01T00:00:00Z20222026-03-27T16:43:22.591Z2025-04-04T08:58:21.551ZS-EPMC88445613517841310.3389/fmed.2022.823900