{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dehner CA"],"funding":["Arthritis Foundation","NCATS NIH HHS","Lupus Research Alliance","National Institutes of Health","Arthritis National Research Foundation"],"pagination":["100084"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8844718"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(2)"],"pubmed_abstract":["Cutaneous T-cell lymphoma (CTCL) is a life-debilitating malignancy of lymphocytes homing to the skin. Although CTCL is thought to arise from a combination of genetic, epigenetic, and environmental factors, specific triggers are unclear. The skin is colonized by a unique microbiota and is heavily influenced by its interactions. We hypothesized that adaptive immune responses to skin commensals lead to clonal T-cell proliferation and transformation in the appropriate genetic background. We therefore collected lesional and nonlesional skin microbiota from patients with CTCL to study T cell interactions using skin T cell explants and peripheral, skin-homing CD4<sup>+</sup> T cells. By various methods, we identified <i>Bacillus safensis</i> in CTCL lesions, a rare human commensal in healthy skin"],"journal":["JID innovations : skin science from molecules to population health"],"pubmed_title":["Malignant T Cell Activation by a <i>Bacillus</i> Species Isolated from Cutaneous T-Cell Lymphoma Lesions."],"pmcid":["PMC8844718"],"funding_grant_id":["R01AI118855","UL1 TR001863","T32AI07019"],"pubmed_authors":["Pereira MS","Ruff WE","Greiling T","Redanz S","Girardi M","Kriegel MA","Dehner CA","McNiff J"],"additional_accession":[]},"is_claimable":false,"name":"Malignant T Cell Activation by a <i>Bacillus</i> Species Isolated from Cutaneous T-Cell Lymphoma Lesions.","description":"Cutaneous T-cell lymphoma (CTCL) is a life-debilitating malignancy of lymphocytes homing to the skin. Although CTCL is thought to arise from a combination of genetic, epigenetic, and environmental factors, specific triggers are unclear. The skin is colonized by a unique microbiota and is heavily influenced by its interactions. We hypothesized that adaptive immune responses to skin commensals lead to clonal T-cell proliferation and transformation in the appropriate genetic background. We therefore collected lesional and nonlesional skin microbiota from patients with CTCL to study T cell interactions using skin T cell explants and peripheral, skin-homing CD4<sup>+</sup> T cells. By various methods, we identified <i>Bacillus safensis</i> in CTCL lesions, a rare human commensal in healthy skin","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T22:14:47.74Z","creation":"2024-11-07T08:21:50.83Z"},"accession":"S-EPMC8844718","cross_references":{"pubmed":["35199089"],"doi":["10.1016/j.xjidi.2021.100084"]}}