biostudies-literatureLi HClarkson UniversityBill and Melinda Gates Foundation242-250https://www.ebi.ac.uk/biostudies/studies/S-EPMC8845047biostudies-literatureUnknown2(2)Hydrogen peroxide (HP) production via electrochemical oxygen reduction reaction (ORR-HP) is a critical reaction for energy storage and environmental remediation. The onsite production of high-concentration H₂O₂ using gas diffusion electrodes (GDEs) fed by air is especially attractive. However, many studies indicate that the air-GDE combination could not produce concentrated H₂O₂, as the [H₂O₂] leveled off or even decreased with the increasing reaction time. This study proves that the limiting factors are not the oxygen concentration in the air but the anodic and cathodic depletion of the as-formed H₂O₂. We proved that the anodic depletion could be excluded by adopting a divided electrolytic cell. FurtheACS ES&T engineeringElectrosynthesis of >20 g/L H₂O₂ from Air.PMC8845047INV-003227Li HYang YQuispe-Cardenas EYang SYin LfalseElectrosynthesis of >20 g/L H₂O₂ from Air.Hydrogen peroxide (HP) production via electrochemical oxygen reduction reaction (ORR-HP) is a critical reaction for energy storage and environmental remediation. The onsite production of high-concentration H₂O₂ using gas diffusion electrodes (GDEs) fed by air is especially attractive. However, many studies indicate that the air-GDE combination could not produce concentrated H₂O₂, as the [H₂O₂] leveled off or even decreased with the increasing reaction time. This study proves that the limiting factors are not the oxygen concentration in the air but the anodic and cathodic depletion of the as-formed H₂O₂. We proved that the anodic depletion could be excluded by adopting a divided electrolytic cell. Furthe2022-01-01T00:00:00Z2022 Feb2025-04-05T13:08:15.336Z2025-04-05T13:08:15.336ZS-EPMC88450473517852910.1021/acsestengg.1c00366