{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Hamad M"],"pubmed_abstract":["The serious challenge posed by multidrug-resistant bacterial infections with concomitant treatment failure and high mortality rates presents an urgent threat to the global health. We herein report the discovery of a new class of potent antimicrobial compounds that are highly effective against Gram-positive bacteria, including methicillin-resistant <i>Staphylococcus aureus</i> (MRSA). The compounds were efficiently synthesized in one-pot employing a cascade of Groebke-Blackburn-Bienaymé and aza-Michael addition reactions. Phenotypic screening of the pilot library against various bacterial species including methicillin-sensitive and MRSA strains, has identified potent chemotypes with minimal inhibitory concentrations (MIC) of 3.125-6.25 μg/ml. The most potent compounds were fast-acting at er"],"journal":["Frontiers in microbiology"],"pagination":["823394"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8846302"],"repository":["biostudies-literature"],"pubmed_title":["Antibacterial Activity of Small Molecules Which Eradicate Methicillin-Resistant <i>Staphylococcus aureus</i> Persisters."],"pmcid":["PMC8846302"],"pubmed_authors":["Hamad M","Al-Tel TH","Al-Marzooq F","Sulaiman A","Zaher DM","Srinivasulu V","Omar HA","Orive G"],"additional_accession":[]},"is_claimable":false,"name":"Antibacterial Activity of Small Molecules Which Eradicate Methicillin-Resistant <i>Staphylococcus aureus</i> Persisters.","description":"The serious challenge posed by multidrug-resistant bacterial infections with concomitant treatment failure and high mortality rates presents an urgent threat to the global health. We herein report the discovery of a new class of potent antimicrobial compounds that are highly effective against Gram-positive bacteria, including methicillin-resistant <i>Staphylococcus aureus</i> (MRSA). The compounds were efficiently synthesized in one-pot employing a cascade of Groebke-Blackburn-Bienaymé and aza-Michael addition reactions. Phenotypic screening of the pilot library against various bacterial species including methicillin-sensitive and MRSA strains, has identified potent chemotypes with minimal inhibitory concentrations (MIC) of 3.125-6.25 μg/ml. The most potent compounds were fast-acting at er","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-26T12:19:27.603Z","creation":"2025-04-06T13:55:31.333Z"},"accession":"S-EPMC8846302","cross_references":{"pubmed":["35178043"],"doi":["10.3389/fmicb.2022.823394"]}}