biostudies-literatureBizot EFondation ARC pour la Recherche sur le CancerFondation pour la recherche médicale FRMe0194921https://www.ebi.ac.uk/biostudies/studies/S-EPMC8846429biostudies-literatureUnknown66(2)We described and characterized Shiga-toxin-producing Escherichia coli (STEC) strains with high levels of resistance to azithromycin isolated in France between 2004 and 2020. Nine of 1,715 (0.52%) STEC strains were resistant to azithromycin, with an increase since 2017. One isolate carried a plasmid-borne <i>mef</i>(C)-<i>mph</i>(G) gene combination, described here for the first time for E. coli. Azithromycin resistance, although rare, needs consideration, as this treatment may be useful in cases of STEC infection.Antimicrobial agents and chemotherapyAzithromycin Resistance in Shiga Toxin-Producing Escherichia coli in France between 2004 and 2020 and Detection of <i>mef</i>(C)-<i>mph</i>(G) Genes.PMC8846429DOC20190509066EQU201903007848Magnan MBirgy ACamelena FBidet PLiguori SBercot BBizot ECointe AMariani-Kurkdjian PLefevre SHobson CABonacorsi SMerimeche MCourroux CWeill FXBridier-Nahmias AfalseAzithromycin Resistance in Shiga Toxin-Producing Escherichia coli in France between 2004 and 2020 and Detection of <i>mef</i>(C)-<i>mph</i>(G) Genes.We described and characterized Shiga-toxin-producing Escherichia coli (STEC) strains with high levels of resistance to azithromycin isolated in France between 2004 and 2020. Nine of 1,715 (0.52%) STEC strains were resistant to azithromycin, with an increase since 2017. One isolate carried a plasmid-borne <i>mef</i>(C)-<i>mph</i>(G) gene combination, described here for the first time for E. coli. Azithromycin resistance, although rare, needs consideration, as this treatment may be useful in cases of STEC infection.2022-01-01T00:00:00Z2022 Feb2025-04-04T13:25:50.634Z2024-11-19T16:34:40.08ZS-EPMC88464293487109110.1128/AAC.01949-2110.1128/aac.01949-21