{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Saposnik G"],"funding":["Roche Farma"],"pagination":["e0264006"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8846509"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(2)"],"pubmed_abstract":["<h4>Background</h4>The therapeutic landscape for spinal muscular atrophy has changed in the last few years, encompassing respiratory/motor function and life expectancy benefits. However, physicians still have the challenge of tailoring individuals' treatment to therapeutic goals, disease progression, patient/caregiver's preferences, and personal experience to achieve an optimal risk/benefit balance. This study aims to provide insight into the preferred treatment choices of pediatric neurologists managing spinal muscular atrophy in their daily practice and to recognize behavioral factors that may influence decision-making.<h4>Methods</h4>This is a noninterventional, cross-sectional pilot study involving 50 pediatric neurologists managing spinal muscular atrophy in Spain. We designed an onli"],"journal":["PloS one"],"pubmed_title":["Therapeutic decisions under uncertainty for spinal muscular atrophy: The DECISIONS-SMA study protocol."],"pmcid":["PMC8846509"],"funding_grant_id":["SL42765"],"pubmed_authors":["Saposnik G","Terzaghi M","Malaga I","Maurino J","Diaz-Abos P","Branas-Pampillon M","Alvarez C","Sanchez-Menendez V"],"additional_accession":[]},"is_claimable":false,"name":"Therapeutic decisions under uncertainty for spinal muscular atrophy: The DECISIONS-SMA study protocol.","description":"<h4>Background</h4>The therapeutic landscape for spinal muscular atrophy has changed in the last few years, encompassing respiratory/motor function and life expectancy benefits. However, physicians still have the challenge of tailoring individuals' treatment to therapeutic goals, disease progression, patient/caregiver's preferences, and personal experience to achieve an optimal risk/benefit balance. This study aims to provide insight into the preferred treatment choices of pediatric neurologists managing spinal muscular atrophy in their daily practice and to recognize behavioral factors that may influence decision-making.<h4>Methods</h4>This is a noninterventional, cross-sectional pilot study involving 50 pediatric neurologists managing spinal muscular atrophy in Spain. We designed an onli","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T19:58:14.694Z","creation":"2025-04-04T19:58:14.694Z"},"accession":"S-EPMC8846509","cross_references":{"pubmed":["35167619"],"doi":["10.1371/journal.pone.0264006"]}}