{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Pankaew S"],"funding":["Canceropôle PACA","Agence Nationale de la Recherche","Horizon 2020 Framework Programme","Centre National de la Recherche Scientifique","Institut National de la Santé et de la Recherche Médicale"],"pubmed_abstract":["PTEN (Phosphatase and TENsin homolog) is a well-known tumor suppressor involved in numerous types of cancer, including T-cell acute lymphoblastic leukemia (T-ALL). In human, loss-of-function mutations of <i>PTEN</i> are correlated to mature T-ALL expressing a T-cell receptor (TCR) at their cell surface. In accordance with human T-ALL, inactivation of <i>Pten</i> gene in mouse thymocytes induces TCRαβ<sup>+</sup> T-ALL development. Herein, we explored the functional interaction between TCRαβ signaling and PTEN. First, we performed single-cell RNA sequencing (scRNAseq) of PTEN-deficient and PTEN-proficient thymocytes. Bioinformatic analysis of our scRNAseq data showed that pathological Pten<sup>del</sup> thymocytes express, as expected, <i>Myc</i> transcript, whereas inference of pathway act"],"journal":["Frontiers in immunology"],"pagination":["797244"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8847596"],"repository":["biostudies-literature"],"pubmed_title":["Calcium Signaling Is Impaired in PTEN-Deficient T Cell Acute Lymphoblastic Leukemia."],"pmcid":["PMC8847596"],"pubmed_authors":["Pankaew S","Nozais M","Remy E","Loosveld M","Potier D","Quessada J","Payet-Bornet D","Grosjean C"],"additional_accession":[]},"is_claimable":false,"name":"Calcium Signaling Is Impaired in PTEN-Deficient T Cell Acute Lymphoblastic Leukemia.","description":"PTEN (Phosphatase and TENsin homolog) is a well-known tumor suppressor involved in numerous types of cancer, including T-cell acute lymphoblastic leukemia (T-ALL). In human, loss-of-function mutations of <i>PTEN</i> are correlated to mature T-ALL expressing a T-cell receptor (TCR) at their cell surface. In accordance with human T-ALL, inactivation of <i>Pten</i> gene in mouse thymocytes induces TCRαβ<sup>+</sup> T-ALL development. Herein, we explored the functional interaction between TCRαβ signaling and PTEN. First, we performed single-cell RNA sequencing (scRNAseq) of PTEN-deficient and PTEN-proficient thymocytes. Bioinformatic analysis of our scRNAseq data showed that pathological Pten<sup>del</sup> thymocytes express, as expected, <i>Myc</i> transcript, whereas inference of pathway act","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-31T02:07:19.829Z","creation":"2025-04-04T23:01:43.88Z"},"accession":"S-EPMC8847596","cross_references":{"pubmed":["35185889"],"doi":["10.3389/fimmu.2022.797244"]}}