{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Muller L"],"funding":["Intramural NIH HHS","NIDA NIH HHS"],"pagination":["1716-1728"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8848835"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(8)"],"pubmed_abstract":["Mass spectrometry imaging (MSI) of tissue implanted with silver nanoparticulate (AgNP) matrix generates reproducible imaging of lipids in rodent models of disease and injury. Gas-phase production and acceleration of size-selected 8 nm AgNP is followed by controlled ion beam rastering and soft landing implantation of 500 eV AgNP into tissue. Focused 337 nm laser desorption produces high quality images for most lipid classes in rat brain tissue (in positive mode: galactoceramides, diacylglycerols, ceramides, phosphatidylcholines, cholesteryl ester, and cholesterol, and in negative ion mode: phosphatidylethanolamides, sulfatides, phosphatidylinositol, and sphingomyelins). Image reproducibility in serial sections of brain tissue is achieved within <10% tolerance by selecting argentated instead"],"journal":["Journal of the American Society for Mass Spectrometry"],"pubmed_title":["Laser Desorption/Ionization Mass Spectrometric Imaging of Endogenous Lipids from Rat Brain Tissue Implanted with Silver Nanoparticles."],"pmcid":["PMC8848835"],"funding_grant_id":["R44 DA030853","RC3 DA031431","Z99 DA999999"],"pubmed_authors":["Muller L","Roux A","McCully MI","Lewis EK","Woods AS","Baldwin K","Balaban CD","Jackson SN","Brinson BE","Schultz JA","Barbacci DC"],"additional_accession":[]},"is_claimable":false,"name":"Laser Desorption/Ionization Mass Spectrometric Imaging of Endogenous Lipids from Rat Brain Tissue Implanted with Silver Nanoparticles.","description":"Mass spectrometry imaging (MSI) of tissue implanted with silver nanoparticulate (AgNP) matrix generates reproducible imaging of lipids in rodent models of disease and injury. Gas-phase production and acceleration of size-selected 8 nm AgNP is followed by controlled ion beam rastering and soft landing implantation of 500 eV AgNP into tissue. Focused 337 nm laser desorption produces high quality images for most lipid classes in rat brain tissue (in positive mode: galactoceramides, diacylglycerols, ceramides, phosphatidylcholines, cholesteryl ester, and cholesterol, and in negative ion mode: phosphatidylethanolamides, sulfatides, phosphatidylinositol, and sphingomyelins). Image reproducibility in serial sections of brain tissue is achieved within <10% tolerance by selecting argentated instead","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Aug","modification":"2025-04-22T01:47:35.423Z","creation":"2025-04-05T20:06:04.027Z"},"accession":"S-EPMC8848835","cross_references":{"pubmed":["28432654"],"doi":["10.1007/s13361-017-1665-4"]}}