{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vera-Mansilla J"],"funding":["Agencia Nacional de Investigación y Desarrollo","ANID | Fondo Nacional de Desarrollo Científico y Tecnológico"],"pagination":["e0167821"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8849078"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["Urinary tract infections (UTIs) are the second most frequent bacterial infections worldwide, with Escherichia coli being the main causative agent. The increase of antibiotic-resistance determinants among isolates from clinical samples, including UTIs, makes the development of novel therapeutic strategies a necessity. In this context, the use of bacteriophages as a therapeutic alternative has been proposed, due to their ability to efficiently kill bacteria. In this work, we isolated and characterized three novel bacteriophages, microbes laboratory phage 1 (MLP1), MLP2, and MLP3, belonging to the <i>Chaseviridae</i>, <i>Myoviridae</i>, and <i>Podoviridae</i> families, respectively. These phages efficiently infect and kill laboratory reference strains and multidrug-resistant clinical E. coli "],"journal":["Microbiology spectrum"],"pubmed_title":["Isolation and Characterization of Novel Lytic Phages Infecting Multidrug-Resistant Escherichia coli."],"pmcid":["PMC8849078"],"funding_grant_id":["PB-01","11190158","11190049"],"pubmed_authors":["Sanchez P","Silva-Valenzuela CA","Vera-Mansilla J","Molina-Quiroz RC"],"additional_accession":[]},"is_claimable":false,"name":"Isolation and Characterization of Novel Lytic Phages Infecting Multidrug-Resistant Escherichia coli.","description":"Urinary tract infections (UTIs) are the second most frequent bacterial infections worldwide, with Escherichia coli being the main causative agent. The increase of antibiotic-resistance determinants among isolates from clinical samples, including UTIs, makes the development of novel therapeutic strategies a necessity. In this context, the use of bacteriophages as a therapeutic alternative has been proposed, due to their ability to efficiently kill bacteria. In this work, we isolated and characterized three novel bacteriophages, microbes laboratory phage 1 (MLP1), MLP2, and MLP3, belonging to the <i>Chaseviridae</i>, <i>Myoviridae</i>, and <i>Podoviridae</i> families, respectively. These phages efficiently infect and kill laboratory reference strains and multidrug-resistant clinical E. coli ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2026-06-07T03:18:38.359Z","creation":"2025-05-18T12:32:48.268Z"},"accession":"S-EPMC8849078","cross_references":{"pubmed":["35171030"],"doi":["10.1128/spectrum.01678-21"]}}