{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(2)"],"submitter":["Stockfleth E"],"funding":["Pierre-Fabre Dermatologie"],"pubmed_abstract":["<h4>Introduction</h4>Actinic keratoses (AK) are epithelial lesions caused by chronic skin exposure to ultraviolet light that can progress into squamous cell carcinoma. Although several treatments are effective, they are associated with severe skin reactions, which might be related to the extent of the disease. This study aimed to examine the relationship between the severity of local skin reactions during treatment with 5-fluorouracil 4% cream and the number of AK lesions at baseline.<h4>Methods</h4>This post hoc analysis pooled data from two multicentre randomised phase III studies (HD-FUP3B-048, HD-FUP3B-049) in patients with AK treated with topical 5-fluorouracil 4% once daily (OD) or 5% twice daily (BID) for 4 weeks. First, we compared the severity, assessed using a numerical rating sc"],"journal":["Dermatology and therapy"],"pagination":["467-479"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8850465"],"repository":["biostudies-literature"],"pubmed_title":["Intensity of Local Skin Reactions During 5-Fluorouracil Treatment Related to the Number of Actinic Keratosis Lesions: A Post Hoc, Exploratory Analysis."],"pmcid":["PMC8850465"],"pubmed_authors":["Stockfleth E","Delarue A","Begeault N"],"additional_accession":[]},"is_claimable":false,"name":"Intensity of Local Skin Reactions During 5-Fluorouracil Treatment Related to the Number of Actinic Keratosis Lesions: A Post Hoc, Exploratory Analysis.","description":"<h4>Introduction</h4>Actinic keratoses (AK) are epithelial lesions caused by chronic skin exposure to ultraviolet light that can progress into squamous cell carcinoma. Although several treatments are effective, they are associated with severe skin reactions, which might be related to the extent of the disease. This study aimed to examine the relationship between the severity of local skin reactions during treatment with 5-fluorouracil 4% cream and the number of AK lesions at baseline.<h4>Methods</h4>This post hoc analysis pooled data from two multicentre randomised phase III studies (HD-FUP3B-048, HD-FUP3B-049) in patients with AK treated with topical 5-fluorouracil 4% once daily (OD) or 5% twice daily (BID) for 4 weeks. First, we compared the severity, assessed using a numerical rating sc","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-21T23:13:02.164Z","creation":"2025-04-05T19:07:17.535Z"},"accession":"S-EPMC8850465","cross_references":{"pubmed":["34954811"],"doi":["10.1007/s13555-021-00668-9"]}}