{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8"],"submitter":["Molinero M"],"pubmed_abstract":["<h4>Background</h4>The pathophysiology of COVID-19-related critical illness is not completely understood. Here, we analyzed the microRNA (miRNA) profile of bronchial aspirate (BAS) samples from COVID-19 and non-COVID-19 patients admitted to the ICU to identify prognostic biomarkers of fatal outcomes and to define molecular pathways involved in the disease and adverse events.<h4>Methods</h4>Two patient populations were included (<i>n</i> = 89): (i) a study population composed of critically ill COVID-19 and non-COVID-19 patients; (ii) a prospective study cohort composed of COVID-19 survivors and non-survivors among patients assisted by invasive mechanical ventilation (IMV). BAS samples were obtained by bronchoaspiration during the ICU stay. The miRNA profile was analyzed using RT-qPCR. Detai"],"journal":["Frontiers in medicine"],"pagination":["756517"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8850692"],"repository":["biostudies-literature"],"pubmed_title":["Bronchial Aspirate-Based Profiling Identifies MicroRNA Signatures Associated With COVID-19 and Fatal Disease in Critically Ill Patients."],"pmcid":["PMC8850692"],"pubmed_authors":["Penuelas O","Gort-Paniello C","de Gonzalo-Calvo D","Torres G","Cabo R","Fernandez-Barat L","Garcia-Gasulla D","Benitez ID","Bermejo-Martin JF","Barbe F","Molinero M","Vengoechea JJ","Moncusi-Moix A","Caballero J","Gonzalez J","Motos A","Riera J","Ferrer R","Gomez S","Rodriguez-Jara F","Garcia-Hidalgo MC","Ceccato A","Torres A","Menendez R"],"additional_accession":[]},"is_claimable":false,"name":"Bronchial Aspirate-Based Profiling Identifies MicroRNA Signatures Associated With COVID-19 and Fatal Disease in Critically Ill Patients.","description":"<h4>Background</h4>The pathophysiology of COVID-19-related critical illness is not completely understood. Here, we analyzed the microRNA (miRNA) profile of bronchial aspirate (BAS) samples from COVID-19 and non-COVID-19 patients admitted to the ICU to identify prognostic biomarkers of fatal outcomes and to define molecular pathways involved in the disease and adverse events.<h4>Methods</h4>Two patient populations were included (<i>n</i> = 89): (i) a study population composed of critically ill COVID-19 and non-COVID-19 patients; (ii) a prospective study cohort composed of COVID-19 survivors and non-survivors among patients assisted by invasive mechanical ventilation (IMV). BAS samples were obtained by bronchoaspiration during the ICU stay. The miRNA profile was analyzed using RT-qPCR. Detai","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-29T10:59:59.824Z","creation":"2025-04-06T19:49:49.91Z"},"accession":"S-EPMC8850692","cross_references":{"pubmed":["35186962"],"doi":["10.3389/fmed.2021.756517"]}}