{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yao X"],"funding":["Fundamental Research Funds for the Central Universities","Jiangsu Agriculture Research System","Jiangsu Planned Projects for Postdoctoral Research Funds","National Natural Science Foundation of China"],"pagination":["820558"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8850840"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10"],"pubmed_abstract":["DNA methylation plays an important role in biological processes by affecting gene expression. However, how DNA methylation regulates phenotypic variation in Hu sheep remains unclear. Therefore, we generated genome-wide DNA methylation and transcriptomic profiles in the ovaries of Hu sheep with different prolificacies and genotypes (FecBB and FecB+). Results showed that ovary DNA methylome and transcriptome were significantly different between high prolificacy and low prolificacy Hu sheep. Comparative methylome analyses identified 10,644, 9,594, and 12,214 differentially methylated regions and 87, 1,121, and 2,375 genes, respectively, showing differential expression levels in three different comparison groups. Female reproduction-associated differentially methylated regions-related genes an"],"journal":["Frontiers in cell and developmental biology"],"pubmed_title":["Integrative Genome-Wide DNA Methylome and Transcriptome Analysis of Ovaries from Hu Sheep with High and Low Prolific."],"pmcid":["PMC8850840"],"funding_grant_id":["JATS[2020]123","32002174 31872357","KJQN202130","2021K254B"],"pubmed_authors":["Ei-Samahy MA","Feng X","Li F","Wang F","Yao X","Wei Z","Yang F"],"additional_accession":[]},"is_claimable":false,"name":"Integrative Genome-Wide DNA Methylome and Transcriptome Analysis of Ovaries from Hu Sheep with High and Low Prolific.","description":"DNA methylation plays an important role in biological processes by affecting gene expression. However, how DNA methylation regulates phenotypic variation in Hu sheep remains unclear. Therefore, we generated genome-wide DNA methylation and transcriptomic profiles in the ovaries of Hu sheep with different prolificacies and genotypes (FecBB and FecB+). Results showed that ovary DNA methylome and transcriptome were significantly different between high prolificacy and low prolificacy Hu sheep. Comparative methylome analyses identified 10,644, 9,594, and 12,214 differentially methylated regions and 87, 1,121, and 2,375 genes, respectively, showing differential expression levels in three different comparison groups. Female reproduction-associated differentially methylated regions-related genes an","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-22T01:42:45.732Z","creation":"2025-04-05T20:07:16.732Z"},"accession":"S-EPMC8850840","cross_references":{"pubmed":["35186931"],"doi":["10.3389/fcell.2022.820558"]}}