{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lemos JRN"],"funding":["Diabetes Research Institute Foundation","National Center for Advancing Translational Sciences","American Diabetes Association COVID-19 Research Award","National Institutes of Health awards","Miami Clinical and Translational Science Institute","US Department of Veterans Affairs Merit Review Award","NIMHD NIH HHS","Juvenile Diabetes Research Foundation International","National Institutes of Health","State of Florida","National Institute on Minority Health and Health Disparities","NIH HHS"],"pagination":["e973-e979"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8852206"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["107(3)"],"pubmed_abstract":["<h4>Background</h4>Islet transplantation (ITx) has proved to be effective in preventing severe hypoglycemia and improving metabolic control in selected subjects with type 1 diabetes. Long-term graft function remains a challenge. Estrogens have been shown to protect β cells from metabolic stresses and improve revascularization of transplanted human islets in the mouse. We aimed to evaluate the influence of sex in allograft survival of ITx recipients.<h4>Methods</h4>We analyzed a retrospective cohort of ITx recipients (n = 56) followed-up for up to 20 years. Allograft failure was defined as a stimulated C-peptide <0.3 ng/mL during a mixed-meal tolerance test. Subjects were divided into recipients of at least 1 female donor (group 1) and recipients of male donors only (group 2).<h4>Results</h"],"journal":["The Journal of clinical endocrinology and metabolism"],"pubmed_title":["Prolonged Islet Allograft Function is Associated With Female Sex in Patients After Islet Transplantation."],"pmcid":["PMC8852206"],"funding_grant_id":["R01 DK55347","7-20-COVID-051","DK070460","DK074970","17-2012-361","BX003725","UL1TR000460","4-2004-361","R01 DK056953","R01 DK025802","4-200-946","U42 RR016603","M01RR16587","DK107444","3-SRA-2017-347-M-B"],"pubmed_authors":["Mauvais-Jarvis F","Poggioli R","Lemos JRN","Fuenmayor V","Alejandro R","Alvarez A","Linetsky E","Ricordi C","Chavez C","Baidal DA"],"additional_accession":[]},"is_claimable":false,"name":"Prolonged Islet Allograft Function is Associated With Female Sex in Patients After Islet Transplantation.","description":"<h4>Background</h4>Islet transplantation (ITx) has proved to be effective in preventing severe hypoglycemia and improving metabolic control in selected subjects with type 1 diabetes. Long-term graft function remains a challenge. Estrogens have been shown to protect β cells from metabolic stresses and improve revascularization of transplanted human islets in the mouse. We aimed to evaluate the influence of sex in allograft survival of ITx recipients.<h4>Methods</h4>We analyzed a retrospective cohort of ITx recipients (n = 56) followed-up for up to 20 years. Allograft failure was defined as a stimulated C-peptide <0.3 ng/mL during a mixed-meal tolerance test. Subjects were divided into recipients of at least 1 female donor (group 1) and recipients of male donors only (group 2).<h4>Results</h","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-04T22:33:57.32Z","creation":"2025-02-19T03:23:47.487Z"},"accession":"S-EPMC8852206","cross_references":{"pubmed":["34727179"],"doi":["10.1210/clinem/dgab787"]}}