biostudies-literatureLemos JRNDiabetes Research Institute FoundationNational Center for Advancing Translational SciencesAmerican Diabetes Association COVID-19 Research AwardNational Institutes of Health awardsMiami Clinical and Translational Science InstituteUS Department of Veterans Affairs Merit Review AwardNIMHD NIH HHSJuvenile Diabetes Research Foundation InternationalNational Institutes of HealthState of FloridaNational Institute on Minority Health and Health DisparitiesNIH HHSe973-e979https://www.ebi.ac.uk/biostudies/studies/S-EPMC8852206biostudies-literatureUnknown107(3)<h4>Background</h4>Islet transplantation (ITx) has proved to be effective in preventing severe hypoglycemia and improving metabolic control in selected subjects with type 1 diabetes. Long-term graft function remains a challenge. Estrogens have been shown to protect β cells from metabolic stresses and improve revascularization of transplanted human islets in the mouse. We aimed to evaluate the influence of sex in allograft survival of ITx recipients.<h4>Methods</h4>We analyzed a retrospective cohort of ITx recipients (n = 56) followed-up for up to 20 years. Allograft failure was defined as a stimulated C-peptide <0.3 ng/mL during a mixed-meal tolerance test. Subjects were divided into recipients of at least 1 female donor (group 1) and recipients of male donors only (group 2).<h4>Results</hThe Journal of clinical endocrinology and metabolismProlonged Islet Allograft Function is Associated With Female Sex in Patients After Islet Transplantation.PMC8852206R01 DK553477-20-COVID-051DK070460DK07497017-2012-361BX003725UL1TR0004604-2004-361R01 DK056953R01 DK0258024-200-946U42 RR016603M01RR16587DK1074443-SRA-2017-347-M-BMauvais-Jarvis FPoggioli RLemos JRNFuenmayor VAlejandro RAlvarez ALinetsky ERicordi CChavez CBaidal DAfalseProlonged Islet Allograft Function is Associated With Female Sex in Patients After Islet Transplantation.<h4>Background</h4>Islet transplantation (ITx) has proved to be effective in preventing severe hypoglycemia and improving metabolic control in selected subjects with type 1 diabetes. Long-term graft function remains a challenge. Estrogens have been shown to protect β cells from metabolic stresses and improve revascularization of transplanted human islets in the mouse. We aimed to evaluate the influence of sex in allograft survival of ITx recipients.<h4>Methods</h4>We analyzed a retrospective cohort of ITx recipients (n = 56) followed-up for up to 20 years. Allograft failure was defined as a stimulated C-peptide <0.3 ng/mL during a mixed-meal tolerance test. Subjects were divided into recipients of at least 1 female donor (group 1) and recipients of male donors only (group 2).<h4>Results</h2022-01-01T00:00:00Z2022 Feb2025-04-04T22:33:57.32Z2025-02-19T03:23:47.487ZS-EPMC88522063472717910.1210/clinem/dgab787