{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8"],"submitter":["Namiguchi K"],"funding":["Ministry of Education, Culture, Sports, Science and Technology"],"pubmed_abstract":["<h4>Objectives</h4>The molecular mechanisms underlying post-operative pericardial adhesions remain poorly understood. We aimed to unveil the temporal molecular and cellular mechanisms underlying tissue dynamics during adhesion formation, including inflammation, angiogenesis, and fibrosis.<h4>Methods and results</h4>We visualized cell-based tissue dynamics during pericardial adhesion using histological evaluations. To determine the molecular mechanism, RNA-seq was performed. Chemical inhibitors were administered to confirm the molecular mechanism underlying adhesion formation. A high degree of adhesion formation was observed during the stages in which collagen production was promoted. Histological analyses showed that arterioles excessively sprouted from pericardial tissues after the accumu"],"journal":["Frontiers in cardiovascular medicine"],"pagination":["761591"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8852280"],"repository":["biostudies-literature"],"pubmed_title":["Unique Angiogenesis From Cardiac Arterioles During Pericardial Adhesion Formation."],"pmcid":["PMC8852280"],"pubmed_authors":["Shikata F","Kubota Y","Ota N","Masumoto J","Okazaki M","Sakaue T","Komoda Y","Kurobe H","Higashiyama S","Kurata M","Izutani H","Nishimura T","Namiguchi K","Kanno K"],"additional_accession":[]},"is_claimable":false,"name":"Unique Angiogenesis From Cardiac Arterioles During Pericardial Adhesion Formation.","description":"<h4>Objectives</h4>The molecular mechanisms underlying post-operative pericardial adhesions remain poorly understood. We aimed to unveil the temporal molecular and cellular mechanisms underlying tissue dynamics during adhesion formation, including inflammation, angiogenesis, and fibrosis.<h4>Methods and results</h4>We visualized cell-based tissue dynamics during pericardial adhesion using histological evaluations. To determine the molecular mechanism, RNA-seq was performed. Chemical inhibitors were administered to confirm the molecular mechanism underlying adhesion formation. A high degree of adhesion formation was observed during the stages in which collagen production was promoted. Histological analyses showed that arterioles excessively sprouted from pericardial tissues after the accumu","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-05-31T08:09:22.536Z","creation":"2025-04-05T15:23:00.802Z"},"accession":"S-EPMC8852280","cross_references":{"pubmed":["35187100"],"doi":["10.3389/fcvm.2021.761591"]}}