biostudies-literatureUnknown8Namiguchi KMinistry of Education, Culture, Sports, Science and Technology<h4>Objectives</h4>The molecular mechanisms underlying post-operative pericardial adhesions remain poorly understood. We aimed to unveil the temporal molecular and cellular mechanisms underlying tissue dynamics during adhesion formation, including inflammation, angiogenesis, and fibrosis.<h4>Methods and results</h4>We visualized cell-based tissue dynamics during pericardial adhesion using histological evaluations. To determine the molecular mechanism, RNA-seq was performed. Chemical inhibitors were administered to confirm the molecular mechanism underlying adhesion formation. A high degree of adhesion formation was observed during the stages in which collagen production was promoted. Histological analyses showed that arterioles excessively sprouted from pericardial tissues after the accumuFrontiers in cardiovascular medicine761591https://www.ebi.ac.uk/biostudies/studies/S-EPMC8852280biostudies-literatureUnique Angiogenesis From Cardiac Arterioles During Pericardial Adhesion Formation.PMC8852280Shikata FKubota YOta NMasumoto JOkazaki MSakaue TKomoda YKurobe HHigashiyama SKurata MIzutani HNishimura TNamiguchi KKanno KfalseUnique Angiogenesis From Cardiac Arterioles During Pericardial Adhesion Formation.<h4>Objectives</h4>The molecular mechanisms underlying post-operative pericardial adhesions remain poorly understood. We aimed to unveil the temporal molecular and cellular mechanisms underlying tissue dynamics during adhesion formation, including inflammation, angiogenesis, and fibrosis.<h4>Methods and results</h4>We visualized cell-based tissue dynamics during pericardial adhesion using histological evaluations. To determine the molecular mechanism, RNA-seq was performed. Chemical inhibitors were administered to confirm the molecular mechanism underlying adhesion formation. A high degree of adhesion formation was observed during the stages in which collagen production was promoted. Histological analyses showed that arterioles excessively sprouted from pericardial tissues after the accumu2021-01-01T00:00:00Z20212026-05-31T08:09:22.536Z2025-04-05T15:23:00.802ZS-EPMC88522803518710010.3389/fcvm.2021.761591